Preparation of Various Solid-Lipid Beads for Drug Delivery of Enrofloxacin |
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Authors: | Eun-Hee Kim |
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Institution: | 1. College of Pharmacy Chosun University Gwangju, Korea;2. and Research Center for Resistant Cells Chosun University, Gwangju, Korea |
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Abstract: | Solid-lipid beads were prepared to retard the release rate of enrofloxacin and to mask its bitter taste using carrageenan or sodium alginate as a shell material and either cacao butter or Witepsol W-35 as a solid lipid core. Sodium alginate was a better shell material than carrageenan and the highest loading efficiency was obtained using 2% sodium alginate. The alginate beads had a spherical morphology and a sturdy shell structure. The enrofloxacin release rate at room temperature was greatly reduced. Solid-lipid beads have the potential to mask the bitter taste of enrofloxacin and extend its release rate. |
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Keywords: | Carrageenan Enrofloxacin Sodium Alginate Solid-Lipid Bead Taste Masking |
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