Designing and Testing of an Effective Oil-in-Water Microemulsion Drug Delivery System for In Vivo Application |
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| Authors: | S. Gupta S. P. Moulik S. Lala M. K. Basu S. K. Sanyal S. Datta |
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| Affiliation: | 1. Centre for Surface Science, Department of Chemistry, Jadavpur University, KolkataIndia;2. Indian Institute of Chemical Biology, Biomembrane Division, KolkataIndia;3. Department of Chemical Engineering, Jadavpur University, KolkataIndia |
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| Abstract: | The phase behavior of a new psedoternary system of clove oil/Tween 20 has been studied. Several compositions from the single-phase region were selected and their stability toward time, temperature, and electrolytes has been examined. A particular composition(clove oil/Tween 20/water as 5/30/65) was chosen as the drug delivery system from the clear oil-in-water zone of the pseudoternary system. The droplet dimension and the polydispersity state of the particular composition was determined by dynamic light scattering. A bioactive compound quarcetin was encapsulated in the vehicle. The efficacy of the drug in the vehicle was examined against leishmaniasis in hamster models. The hepatotoxicity of the vehicle (o/w microemulsion) with and without the drug quarcetin was examined by estimating serum alkaline phosphatase, glutamate pyruvate transaminase, urea, and creatinine. |
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| Keywords: | Clove Oil Drug Delivery Leishmaniasis Microemulsion Quarcetin |
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