Effect of microneedle on the pharmacokinetics of ketoprofen from its transdermal formulations |
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Authors: | Jae-Woo So Hyoun-Hyang Park Seung S Lee Dong-Chool Kim Sang-Chul Shin |
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Institution: | 1. College of Pharmacy, Chungnam National University, Daejeon, South Korea;2. Department of Mechanical Engineering and Center for Ultramicrochemical Process Systems, Korea Advanced Institute of Science and Technology, Guseong-dong, Yuseong-gu, Daejeon, South Korea;3. College of Pharmacy, Chonnam National University, Kwangju, South Korea |
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Abstract: | Non-invasive transdermal delivery using microneedle arrays was recently introduced to deliver a variety of large and hydrophilic compounds into the skin, including proteins and DNA. In this study, a microneedle array was applied to the delivery of a hydrophobic drug, ketoprofen, to determine if transdermal delivery in rats can be improved without the need for permeation enhancers. The ability of a microneedle to increase the skin permeability of ketoprofen was tested using the following procedure. A microneedle array was inserted into the lower back skin of a rat using a clip for 10 min. Subsequently, 24 mg/kg of a ketoprofen gel was loaded on the same site where the microneedle had been applied. Simultaneously, the microneedle was coated with 24 mg/kg of a ketoprofen gel, and inserted into the skin using a clip for 10 min. As a negative control experiment, only 24 mg/kg of the ketoprofen gel was applied to the shaved lower back of a rat. Blood samples were taken at the indicated times. The plasma concentration (Cp) was obtained as a function of time (t), and the pharmacokinetic parameters were calculated using the BE program. The group loaded with the microneedle coated with ketoprofen gel showed a 1.86-fold and 2.86-fold increase in the AUC and Cmax compared with the ketoprofen gel alone group. These results suggest that a microneedle can be an ideal tool for transdermal delivery products. |
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Keywords: | Microneedle Ketoprofen Gel Pharmacokinetics |
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