Über Derivate des 1-Cyan-1,2,3,4-tetrahydroisochinolins |
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Authors: | H Bhme R Schweitzer |
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Institution: | H. Böhme,R. Schweitzer |
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Abstract: | Substituted 1-Cyano-1,2,34-tetrahydroisoquinolines Addition of hydrocyanic acid to 3,4-dihydroisoquinoline ( 1 ) gives 1-cyano-1,2,3,4-tetrahydroisoquinoline ( 2 ), which can be isolated as hydrochloride ( 3 ). 2 can be acylated to 2-acyl-1-cyano-1,2,3,4-tetrahydroisoquinolines ( 5 ), which can be prepared in a similar way by Reissert synthesis. Alkylation or acylation of 5 results in 1,1-disubstituted tetrahydroisoquinolines of type 4 and 6 . |
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