Controlled release study of 5-fluorouracil-loaded chitosan/polyethylene glycol microparticles |
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| Authors: | Chuen-Chang Lin Chun-Hsien Fu |
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| Institution: | 1. Department of Chemical &2. Materials Engineering, National Yunlin University of Science and Technology, Douliu, Yunlin, Taiwanlinchuen@yuntech.edu.tw;4. Materials Engineering, National Yunlin University of Science and Technology, Douliu, Yunlin, Taiwan |
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| Abstract: | The aim of this research is to reduce the frequency of taking therapeutic drugs. Thus, anti-cancer drug 5-fluorourical (5-FU)] loaded chitosan/polyethylene glycol microparticles were prepared by a phase-inversion technique with tripolyphosphate (TPP) used as a cross-linking agent. The relationships between 5-FU release behavior/encapsulation efficiencies and chitosan concentrations, TPP concentrations, as well as cross-linking time were studied to identify better/superior conditions (3.5 wt% chitosan, 3 wt% TPP, and cross-linking time?=?4?h) for preparing 5-FU-loaded microparticles. Furthermore, in order to ascertain the influence of their physical properties on 5-FU release performance, 5-FU-loaded microparticles were evaluated by swelling tests and scanning electron microscopy. |
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| Keywords: | Chitosan tripolyphosphate phase-inversion 5-fluorourical controlled release |
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