Incidence And Clinical Correlates Of Increased Serum Creatine Kinase Levels In Persons With Spinal Cord Injury |
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| Authors: | Yaga Szlachcic MD Robert L Waters MD Sugantha Govindarajan MD Jiangnan Wang MD Florence Yee PharmD |
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| Institution: | 1. Departments of Medicine, Rancho Los Amigos National Rehabilitation Center, Downey, California;2. Departments of Rehabilitation Research and Training Center on Aging with Spinal Cord, Rancho Los Amigos National Rehabilitation Center, Downey, California;3. Departments of Rehabilitation Research and Training Center on Aging with Spinal Cord, Rancho Los Amigos National Rehabilitation Center, Downey, California;4. Departments of Model Spinal Cord Injury Care System of Southern California, Rancho Los Amigos National Rehabilitation Center, Downey, California;5. Departments of Laboratory/Pathology, Rancho Los Amigos National Rehabilitation Center, Downey, California |
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| Abstract: | AbstractBackground: Elevated plasma levels of creatine kinase (CPK) are found in various neuromuscular conditions as a result of muscle damage and necrosis. Elevated CPK has also been described in elite wheelchair athletes and in able-bodied individuals after strenuous exercise.Methods: The incidence of elevated CPK in individuals with spinal cord injury (SCI) has not been well established. We reviewed laboratory data from 581 individuals with chronic SCI.Results: Most individuals with SCI (73.3%) had CPK values within 95% confidence intervals for able-bodied individuals. The highest levels were seen in African Americans (21% had CPK values > 95 confidence intervals for able-bodied individuals). Significant associations between CPK and the following independent variables were identified: impairment group, gender, duration of injury, body mass index, and ethnic group. Multiple regression analysis revealed significant correlations between CPK and oxygen consumption (beta .37, P < .01) in 32 individuals who performed the exercise test.Conclusions: These findings are important for clinicians evaluating symptoms of fatigue and myopathy in individuals with SCI. |
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| Keywords: | Spinal cord injuries Creatine kinase Myopathy Ethnicity HMG-CoA reductase inhibitor Post-poliomyelitis syndrome |
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