In Vitro Permeation Studies of Nanoemulsions Containing Ketoprofen as a Model Drug |
| |
| Authors: | Beom Su Kim Myoung Won Yang Cheo Sang Kim |
| |
| Affiliation: | 1. Laboratory of Enzyme Technology, College of Natural Science;2. Division of Mechanical Design Engineering, College of Engineering, Chonbuk National University, Chonju |
| |
| Abstract: | We prepared a nanoemulsion system with benzyl alcohol/ ethanol/Solutol/smash® HS 15 /water. Ketoprofen was used as a model drug in this study. The nanoemulsions of this system evidenced a high degree of stability. The droplet diameter did not change over a period of at least 3 months. The nanoemulsion containing 4% benzyl alcohol evidenced a permeation rate higher than was observed with the 1% and 2% nanoemulsions. Also the nanoemulsion containing 1% Solutol® HS 15 provided a permeation rate higher than was seen with the 2% and 4% nanoemulsions. All ketoprofen-loaded nanoemulsions enhanced the in vitro permeation rate through mouse skins as compared to the control. |
| |
| Keywords: | Benzyl Alcohol Ketoprofen Nanoemulsion Skin Permeation Transdermal Delivery |
|
