妇女TORCH感染与先天性心脏病的相关性研究

目的 :了解孕妇 TORCH感染的危害程度 ,临床预防并干预先天性心脏病 ( CHD)患儿的出生。方法 :应用 Ig M捕获免疫技术对健康首胎及 2胎孕妇进行抗人巨细胞 Ig M血清流行病学监测。结果 :首胎孕妇 732 1例 Ig M阳性 880例 ,阳性率为 12 .0 2 % ;2胎 5 2 3例中阳性 93例 ,阳性率 17.80 % ;2 34例有先天性心脏病家族史的孕妇 Ig M阳性率 2 2 .2 2 % ,两者之间差异有高度显著性 ( P<0 .0 1)。随访发现 ,在这些孕妇中其 CHD的出生率分别是 0 .76 % ,2 .6 5 % ,7.6 0 %。结论 :母亲 TORCH感染 ,特别是 CMV感染 ,CMV Ig M抗体阳性与 CHD密切相关 ,开展孕妇 CMV血清流行病学监测具有重要的优生学意义

Correlation between women's TORCH infection and congenital heart disease

Objective:To know harm degree of pregnant women's TORCH infection, to prevent and interfere the birth of infants with congenital heart disease (CHD). Methods:Serum anti-human cytomegalovirus IgM in healthy women for first and second time was monitored epidemiologically with IgM catching immunoassay. Results: Of 7321 cases for first time, there were 880 cases of positive IgM (12.02%); of 523 cases for second time, there were 93 cases of positive IgM (17.03%). 234 pregnant women with CHD family history were positive IgM (22.22%), there were significant difference between two groups ( P <0.01). By following-up, rate of birth with CHD in these pregnant women was 0.76%, 2.65% and 7.60% respectively.Conclusion: If mother with TORCH infection, especially CMV infection, there was tight correlation between CMV IgM positive antibodies and CHD. Thus, monitoring epidemiological serum CMV in pregnant women has important eugenic significance.