慢性阻塞性肺疾病患者血浆脑肽钠和内皮素水平的变化

目的 测定慢性阻塞性肺疾病（COPD）急性加重期（AECOPD）和稳定期患者血浆脑肽钠（BNP）和内皮素（ET）水平的变化，以探讨BNP和ET在COPD发病机制中的作用。方法检测28例AECOPD患者，24例COPD稳定期患者和26名健康对照者的血浆脑肽钠和内皮素含量。结果AECOPD组分别与对照组和COPD组比较，血浆BNP和ET水平明显升高（P〈0．01，P〈0．05；P〈0．01，P〈0．05），COPD患者与对照组比较，血浆BNP和ET水平明显升高（P〈0．05；P〈0．05）。结论COPD患者血浆ET和BNP的变化参与COPD的炎症过程，它们的变化可能与其疾病本身和疾病程度有关。

Changes of plasma brain natriuretie peptide and endothelin in patients with chronic obstructive pulmonary aisease

Objective To measure the level of BNP and ET in patients with chronic ob-structive pulmonary disease (COPD) and therefore to investigate the pathogenesy of BNP and ET in COPD.Methods 28 patients with acute exacerbation of COPD,24 patients with stable COPD,and 26 healthy subjects were recruited, the levels of BNP and ET were measured by radioimmnoassay.Results The levels of BNP and ET were significantly higher in AECOPD patients than in healthy subjects and in stable COPD patients (P < 0.01,P < 0.05 ; P < 0.01 ; P < 0.05), the levels of ET the levels of BNP and ET were significantly higher in stable COPD patients than in healthy subjects (P < 0.05; P < 0.05).Conclusions It is suggested that concentrations of plasma' s BNP and ET changed signifi-cantly in COPD, BNP and ET were possibly involved in pathogenesis of airway inflammation in COPD, and their variations in eoneentrations were related with the development of COPD.