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| 丹蒌片对高脂血症大鼠血管内皮功能的影响 | |
| 引用本文： | 洪铁,杨振,刘玉梅,韩强. 丹蒌片对高脂血症大鼠血管内皮功能的影响[J]. 世界中西医结合杂志, 2010, 5(4): 308-310 |
| 作者姓名： | 洪铁 杨振 刘玉梅 韩强 |
| 作者单位： | 1. 吉林大学药学院,吉林,长春,130021;吉林省中医药科学院,吉林,长春,130021 2. 吉林省中医药科学院,吉林,长春,130021;吉林农业大学中药材学院,吉林,长春,130118 3. 吉林大学中日联谊医院,吉林,长春,130033 4. 吉林康乃尔药业有限公司,吉林,吉林,132013 |
| 摘 要： | 目的研究丹蒌片对高脂血症大鼠血脂水平和血管内皮功能相关指标的影响。方法将48只大鼠随机分为正常组、模型组、辛伐他汀组、丹蒌片组,分别给予基础饲料和高脂饲料喂养,8周后检测各组动物血脂水平及内皮功能的相关指标。结果(1)与模型组比较,辛伐他汀组和丹蒌片组TC、TG的含量明显降低,差异具有统计学意义(P0.05或P0.01)。(2)与模型组比较,辛伐他汀组和丹蒌片组HDL的含量明显升高,LDL的含量明显降低,HDL/LDL比值明显升高,差异具有统计学意义(P0.05)。(3)与模型组比较,辛伐他汀组和丹蒌片组NO、CGRP的含量明显升高,ICAM-1的含量明显降低,差异有统计学意义(P0.05)。(4)与模型组比较,辛伐他汀组和丹蒌片组ET-1、TBX2的含量明显降低,6-keto-PGF la含量明显升高,差异有统计学意义(P0.05)。结论丹蒌片能降低高脂血症大鼠血脂水平,改善血管内皮功能。 |
| 关 键 词： | 丹蒌片 高脂血症 血管内皮功能 大鼠 |
Effects of Danlou Tablets on Vascular Endothelial Function in Hyperlipemia Rats |
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| HONG Tie,YANG Zhen,LIU Yu-mei,HAN Qiang. Effects of Danlou Tablets on Vascular Endothelial Function in Hyperlipemia Rats[J]. World Journal Of Integrated Traditional and Wesrern Medicine, 2010, 5(4): 308-310 | |
| Authors: | HONG Tie YANG Zhen LIU Yu-mei HAN Qiang |
| Affiliation: | HONG Tie1,2,YANG Zhen2,3,LIU Yu-mei4,HAN Qiang5 (1.Pharmaceutical College of Jilin University,Changchun Jilin 130021,2.Jilin College of Traditional Chinese Medicine,3.College of Materia Medica,Jilin Agricultural University,Changchun Jilin 130118,4.China-Japan Friendship Hospital of Jilin University,Changchun Jilin 130033,5.Jilin Connell Pharmaceutical Co.,Ltd.,Jilin Jilin 132013) |
| Abstract: | Objective To study the effect of danlou tablets on blood lipid level and the relevant indexes of vascular endothelial function in hyperlipemia rats.Methods 48 rats were assigned into 4 groups randomly,including normal group,model group,simvastatin group and danlou tablets group.The rats were fed with basic forage and high-lipid forage separately.Blood lipid level and the relevant indexes of endothelial function of animal were detected 8 weeks later in each group.Results 1)Compared with model group,TC and TG... |
| Keywords: | Danlou Tablets Hyperlipemia Vascular Endothelial Function Rats |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |