早期完全性水泡状胎块临床病理分析

目的 探讨早期完全性水泡状胎块的临床病理及免疫组化特征、鉴别诊断及治疗与预后.方法 回顾性分析43例早期完全性水泡状胎块的临床资料、病理学及免疫组化特征以及预后随访.结果 28例早期完全性水泡状胎块以阴道出血为首发症状,21例患者既往有流产史,26例肉眼可见散在大小不一的小水泡.镜下观察部分绒毛增大水肿伴中央水池形成,...

Clinicopathological Analysis of Early Complete Hydatidiform Moles

Objective To investigate the clinicopathological and immunohistochemical features,differential diagnosis and prognosis of early complete moles(ECM).Methods A retrospective analysis was conducted on the clinical data,histopathological and immunohistochemical features and follow-up of the 43 cases of ECM.Results 28 of 43 patients had vaginal bleeding as the first symptom,21 of 43 patients had miscarriage history.Grossly,enlarged villi forming variant transparent vesicles were showed in 26 cases.Histologically,most villi showed striking edema and some contained center cisterns,so did redundant bulbous budding of terminal villi with circumferential trophoblastic sprouts-like proliferation.Besides hyperplasia and cytologic atypia of the intervillous trophoblast and implantation-site trophoblast,there were hypercellular villous stroma with labyrinthine vascular networks associated with myxoid background and karyorrhexis debris.Immunohistochemically,p57 was negative in villous stromal cells and cytotrophoblasts.No gestational trophoblastic diseases occurred during the follow-up on 40 patients.Conclusion ECM has unique clinicopathological and immunohistochemical features and good prognosis.