淋巴管内皮细胞透明质酸受体-1标记的乳腺癌微淋巴管密度测定及其临床意义

目的 探讨淋巴管内皮细胞透明质酸受体1 (LYVE-1)标记的乳腺癌微淋巴管密度测定(MLD)在乳腺癌表达的临床意义.方法 采用免疫组化方法检测54例乳腺癌组织和40例正常乳腺组织的LYVE-1的表达,光镜下观察计数MLD,评价淋巴管增殖情况.结果 LYVE-1阳性表达于肿瘤边缘组织淋巴管内皮细胞,表现为淋巴管扩张明显...

Clinical Significance of Lymph Microvessel Density Marked by Lymphatic Ressel Endothelial Hyaluronic Acid Receptor-1 in Rectal Cancer

Objective To study the Clinical significance of lymph microvessel density(MLD)marked by lymphatic ressel endothelial hyaluronic acid receptor-1(LYVE-1) in rectal cancer.Method LYVE-1were quantitated and located in archival specimens of 54 rectal cancer and normal rectum tissue by immunohistochemisty for the recently described lymphatic.MLD were quantitated,and lymph vessel increment were evaluated.Result LYVE-1 expression in tumor tissue edge of lymphatic endothelial cells,showing dilated lymphatic vessels in the tumor center real expression of the ministry of lymphatic vessels is less,mostly latch-cord-like or gap-like,the edge of breast cancer and the central area of the mean MLD was significantly higher than normal breast mucosa(P<0.05,P<0.01),tumor margin tissue was significantly higher than the mean MLD cancer Center tissue(P <0.05).Conclusion Detection of breast cancer tumor tissue MLD can be used as the occurrence of tumor lymph angiogenesis and lymph node metastasis of an indicator to determine.