早期鼻咽癌的18F-FDG摄取与肿瘤组织葡萄糖易化扩散转运蛋白表达的关系

目的:探讨早期鼻咽癌的18F-FDG摄取与肿瘤组织葡萄糖易化扩散转运蛋白表达的关系。方法:对2005年3月至2006年8月收治的42例早期鼻咽癌患者进行正电子发射体层显像(PET)检查,测定肿瘤最大值和标准摄取值(SUVmax和SUVmean);应用标准链霉菌抗生物素蛋白-过氧化物酶亲和(SP)免疫组化法检测40例患者肿瘤组织葡萄糖易化扩散转运蛋白1(Glut-1)的表达。结果:42例早期鼻咽癌组织的SU-Vmax与SUVmean分别为9.45±1.87和6.04±1.09;40例鼻咽癌组织Glut-1阳性细胞率为45.18%;鼻咽癌组织FDG摄取(SUVmax)和Glut-1表达的细胞阳性率呈弱相关(r=0.369,P=0.019)。结论:早期鼻咽癌组织FDG摄取与Glut-1过度表达相关。

Relationship between fluorodeoxyglucose uptake and overexpression of glucose transporter-1 of early stage nasophygeal carcinoma

Objective:To assess the relationship among the fluorine-18 fluorodeoxyglucose(FDG) uptake and overexpression of facilitative glucose transporter(Glut1) in patients with early-stage nasophageal carcinoma.Methods:From March 2005 to August 2006,42 patients with nasophageal carcinoma of early stage were imaged with FDG positron emission tomography(PET).Their maximum and mean standard uptake value(SUVmax and SUVmean)were measured.The expression of Glut1 of 40 cases was studied in paraffin sections by SP immunohistochemistry.Results:The FDG uptake of tumors of 42 patients with nasophageal carcinoma of early stage were 9.45±1.87(SUV max) and 6.04±1.09(SUVmean) respectively.The Glut-1 positive cells were 45.18% of tumor cell area,and there was correlation between Glut-1 expression and tumors’FDG uptake.Conclusion:Glut-1 overexpression correlates with FDG uptake in patients with early-stage nasophageal carcinoma.