两种双膦酸盐治疗恶性肿瘤骨转移疼痛的药物经济学分析(英文)

目的:研究唑来膦酸和伊班膦酸钠治疗恶性肿瘤骨转移疼痛的药物经济学。方法:45例恶性肿瘤骨转移疼痛的患者随机分为两组,一组接受4mg唑来膦酸治疗,另一组接受4mg伊班膦酸钠治疗,比较两组患者首次住院双膦酸盐治疗的总费用、费用组成、疼痛缓解率、不良反应,进行药物经济学的费用-效果分析。结果:唑来膦酸组(n=23)总费用低于伊班膦酸钠组(n=22),分别为2 409.22元和3 903.64元(P<0.05);两组疼痛缓解有效率分别为78.3%和72.3%,无显著性差异(P>0.05);两组费用-效果比为31.75和53.99;不良反应发生率两组间无显著性差异(P>0.05)。结论:唑来膦酸是治疗恶性肿瘤骨转移的安全、有效、经济的药物。

Pharmacoeconomics of two bisphosphonates in the treatment of metastatic bone pain of malignancy

Objective:To evaluate the pharmacoeconomics of zoledronate in treatment of metastatic bone pain of malignancy,compared with ibandronate.Methods:Total of 45 patients with metastatic bone pain of malignancy were randomly divided into two groups to receive 4 mg zoledronate or 4 mg ibandronate.Total cost,cost composition,pain relief response rate and side effects in the first treatment cycle were assessed.A cost-benefit analysis was conducted.Results: The total cost of zoledronate group (n=23) and ibandronate group (n=22) was 2409.22 yuan and 3903.64 yuan respectively (P<0.05).The pain relief rate was 78.3% and 72.3% respectively (P>0.05).The cost / effect of zoledronate group was lower than that of ibandronate group (31.75 vs 53.99).There were no significant differences in incidence of adverse reactions (P>0.05).Conclusion:Zoledronate is a safe,efficient and economic alternative in the treatment of metastatic bone pain of malignancy.