| 沙利度胺对人卵巢癌裸鼠皮下种植瘤抑瘤作用的研究 |
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| 引用本文： | 杜娟,黄学惠. 沙利度胺对人卵巢癌裸鼠皮下种植瘤抑瘤作用的研究[J]. 现代肿瘤医学, 2011, 19(2): 245-248. DOI: 10.3969/j.issn.1672-4992.2011.02.12 |
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| 作者姓名： | 杜娟 黄学惠 |
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| 作者单位： | 昆明医学院第一附属医院妇科,云南,昆明,650032 |
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| 摘 要： | 目的:探讨沙立度胺(反应停,酞咪哌啶酮,thalidomide)对卵巢癌裸鼠皮下种植瘤的生长抑制作用。方法:建立20只卵巢癌裸鼠荷瘤模型,随机分为4组,每组5只:沙利度胺组:按200mg.kg-1d-1,0.2ml腹腔内注射。顺铂组:2mg.kg-1d-1,0.2ml腹腔内注射。联用组:顺铂与沙利度胺联合应用(顺铂2mg.kg-1d-1,沙利度胺200mg.kg-1d-1,各0.2ml腹腔内注射)。生理盐水组:每只0.2ml生理盐水腹腔内注射。4组给药方法均为自肿瘤种植成功后瘤体直径平均为0.8cm,开始给药,给药2周,每周2次,总共注射4次。观察各组裸鼠体重、皮下种植瘤瘤体直径均值(MTD)的变化,以及各组裸鼠的行动、对外界刺激的反应、饮食、及瘤体表面皮肤的变化,测量各组肿瘤的大小。结果:沙利度胺组、顺铂组、联用组荷瘤体积明显小于生理盐水组,差异有统计学意义(P<0.05),抑瘤率分别为57.47%、42.18%、71.37%。结论:沙利度胺对卵巢癌皮下种植瘤的生长有抑制作用,与传统的化疗药物顺铂联用,可增强化疗药物作用。
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| 关 键 词： | 沙利度胺 顺铂 卵巢癌 裸鼠 生长抑制 |
Study of thalidomide on the growth inhibition of ovary cancer SKOV-3 subcutaneous implanted in nude mice |
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| DU Juan,HUANG Xue-hui. Study of thalidomide on the growth inhibition of ovary cancer SKOV-3 subcutaneous implanted in nude mice[J]. Journal of Modern Oncology, 2011, 19(2): 245-248. DOI: 10.3969/j.issn.1672-4992.2011.02.12 |
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| Authors: | DU Juan HUANG Xue-hui |
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| Affiliation: | DU Juan,HUANG Xue-hui Department of Gynecology,First Affiliated Hospital of Kunming Medical University,Kunming 650032,China |
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| Abstract: | Objective:To study the effect of thalidomide used alone and in combi-nation with cisplatin(DDP) on ovarian cancer cell subcutaneous implanted tumor gro-wth inhibition.Methods:Twenty ovarian cancer modle ubcutaneous implantted in nude m-ice was established and randomly divided into 4 groups,n=5:thalidomide group:200mg.kg-1d-1,0.2ml,ip;DDPgroup:0.2mg.kg-1d-1,0.2ml,ip;Combined treatment group:both Thd and DDP,0.2ml,ip;control group:saline solution,0.2ml,ip.Af-ter the success of implant,MTD 0.8cm,administered t... |
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| Keywords: | thalidomide cisplatin ovarian cancer nude mice growth inhibition |
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