三阴性乳腺癌的临床病理特征及预后因素分析

目的:分析三阴性乳腺癌的临床病理学特征及其影响预后的因素,探索更为有效的治疗方案。方法:收集2000年1月至2005年9月收治的经病理组织学证实、有完整随访资料的510例可手术乳腺癌患者的临床资料,108例(21.2%)患者证实为三阴乳腺癌。比较三阴乳腺癌组与非三阴乳腺癌组的临床特征、复发或远处转移、生存情况。结果:510例患者中108例患者是三阴性乳腺癌,其组织学III级、髓样癌的比例明显高于非三阴性乳腺癌(P<0.05)。三阴性乳腺癌的5年复发或远处转移率(30.8%)明显高于非三阴性(18.7%,P<0.05)。三阴性乳腺癌的5年总生存率(78.4%)明显低于非三阴性(88.1%,P<0.05)。结论:三阴性乳腺癌具有独特的临床病理特征,比非三阴性乳腺癌更易发生局部复发和远处转移,预后较差。

Clinicopathological characteristics and prognosis factors of the triple negative breast cancer

Objective:To analyze the clinicopathological features,prognostic factors of the patients with triple negative breast cancer,and find out effective treatment.Methods:Clinical Data of 510 patients with histopathologically confirmed resectable breast cancer from 2000 to 2005 were analyzed.Of the 510 patients,108(21.2%) were confirmed to be triple-negative breast cancer.The clinical characteristics,local recurrence or distant metastasis,overrall survival of the patients were compared between the triple-negative breast cancer and non-triple negative breast cancer group.Results: Of 510 patients,108(21.2%) had triple negative breast cancer.The rate of local or recurrence or distant metastasis for 5 years in the triple negative breast cancer group(30.8%) was higher than that in the non-triple negative breast cancer group(18.7%,P<0.05).The 5-year overrall survival in the triple negative breast cancer group(78.4%) was lower than that in non-triple negative breast cancer group(88.1%,P<0.05).Conclusion: Triple negative breast cancer has unique clinicopathological features.Compared with non-triple negative breast cancer,it has an increased possibility of local recurrence and distant metastasis,leading a poorer prognosis.