Autonomic responses to sighs in healthy infants and in victims of sudden infant death |
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| Authors: | Franco Patricia Verheulpen Denis Valente Filomena Kelmanson Igor de Broca Alain Scaillet Sonia Groswasser José Kahn André |
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| Affiliation: | 1. Pediatric Sleep Unit, Hôpital Erasme, Brussels, Belgium;2. Pediatric Sleep Unit, University Children''s Hospital, Brussels, Belgium;3. Department of Biostatistics, School of Public Health, Université Libre de Bruxelles, Brussels, Belgium;4. Department of Pediatrics, University of St Petersburg, St Petersburg, Russia;5. Department of Pediatrics, CHU Amiens, Amiens, France;1. CHU Sainte-Justine Research Centre, Montreal, Canada;2. Department of Psychiatry, University of Montreal, Montreal, Canada;3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada;4. Department of Psychology, Concordia University, Montreal, Canada;5. Douglas Mental Health University Institute, Verdun, Canada;6. Department of Psychiatry, McGill University, Montreal, Canada;7. School of Psychoeducation, University of Montreal, Montreal, Canada;8. Department of Psychology and Pediatrics, University of Montreal, Montreal, Canada;9. School of Public Health, Physiotherapy and Sports Science, University College Dublin, Ireland;1. University Hospital and Faculty of Medicine, University of São Paulo, São Paulo, Brazil;2. School of Psychology & Discipline of Psychiatry, University of Sydney, Sydney, Australia;3. Department of Biology, Universidad Autónoma de Madrid, Spain;4. Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;5. Collegiate of Biological Sciences, Federal University of Vale do São Francisco, Petrolina, Pernambuco, Brazil;6. Departament of Physiological Sciences, Federal University of Espírito Santo, Vitória, Brasil, Brazil;7. Hospital das Clínicas and Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil;8. Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH, 43210, USA;1. Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;2. Interdisciplinary Center for Psychopathology and Emotion Regulation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;3. Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands;4. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands;5. Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands;6. Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;1. Behavioral Neuropharmacology and Neuroimaging Laboratory, Research Institute on Addictions, University at Buffalo, 14203, USA;2. Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA;3. Department of Psychiatry and Behavioral Neurosciences, University of Cincinnati, Cincinnati, OH 45237, USA;1. Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, NY 10032, USA;2. Division of Diabetes, Obesity & Metabolism, Oregon National Primate Research Center, Beaverton, OR 97006, USA;3. Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA |
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| Abstract: | OBJECTIVE: Sigh, defined as an isolated breath with an increased tidal volume, can be associated with abrupt changes in heart rate (HR) or blood oxygenation. Sigh may be followed by a central apnea. As impairment of autonomic control was postulated in future SIDS victims, we hypothesized that their autonomic responses to sighs were different from those of healthy control infants. METHODS: Sighs followed by central apnea were studied in the sleep recordings of 18 infants who eventually died of SIDS and of 18 control infants. The infants of the two groups were matched for sex, gestational age, postnatal age, weight at birth and sleep position during sleep recording. HR autoregressive power spectral analysis was performed on RR intervals preceding and following sighs. RESULTS: In all infants, most sighs followed by an apnea were found in NREM sleep. Compared to the control infants, the future SIDS victims were characterized by a greater sympathovagal balance and a lower parasympathetic tonus before the sighs. Following the sighs, no more differences were found in NREM sleep. CONCLUSION: Based on the present findings, it can be postulated that sighs contribute to reset autonomic tonus during NREM sleep. |
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| Keywords: | Autonomic nervous system Infant Sigh Sleep Sudden infant death syndrome |
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