β-N-Acetylhexosaminadases in human cerebrospinal fluid and serum of patients with multiple sclerosis |
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Authors: | Alessandro Datti Carla Emiliani Giuseppe Capocchi Aldo Orlacchio |
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Abstract: | β-N-Acetylhexosaminidase activity and isoenzyme have been investigated in normal human cerebrospinal fluid and that of patients with multiple sclerosis. β-N-acetylhexosaminidase activity in normal cerebrospinal fluids has been resolved into five components. The major component was in a form that eluted from DEAE cellulose at the same salt concentration as hexosaminidase As, the isoenzyme previously identified in human serum. Cerebrospinal fluid from patients exhibited a different isoenzyme profile, showing a remarkable increase in a form having a pI which was more acidic than that of As. These changes have a potential use in the diagnosis and further biochemical characterization of multiple sclerosis. |
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Keywords: | β -N-Acetylhexosamimidase Automated procedure Human cerebrospinal fluid Human serum Multiple sclerosis |
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