Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers |
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Authors: | G. Bano R. K. Raina U. Zutshi K. L. Bedi R. K. Johri S. C. Sharma |
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Affiliation: | (1) Department of Pharmacology and Therapeutics, Government Medical College, Jammu-Tawi, India;(2) Regional Research Laboratory, Jammu-Tawi, India |
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Abstract: | Summary The effect of piperine on the bioavailability and pharmacokinetics of propranolol and theophylline has been examined in a crossover study. Six subjects in each group received a single oral dose of propranolol 40 mg or theophylline (150 mg) alone or in combination with piperine 20 mg daily for 7 days. An earlier tmax and a higher Cmax and AUC were observed in the subjects who received piperine and propranolol. It produced a higher Cmax, longer elimination half-life and a higher AUC with theophylline.In clinical practice, the enhanced systemic availability of oral propranolol and theophylline could be exploited to achieve better therapeutic control and improved patient compliance. |
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Keywords: | Piperine Propranolol Theophylline pharmacokinetics drug interaction |
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