| WB_(852)抗肿瘤作用及对癌细胞内环核苷酸的影响 |
| |
| 引用本文： | 景永奎,张宝凤,孙鉴镗,聂连之,刘忠林,苏兴仁.WB_(852)抗肿瘤作用及对癌细胞内环核苷酸的影响[J].沈阳药科大学学报,1992(3). |
| |
| 作者姓名： | 景永奎 张宝凤 孙鉴镗 聂连之 刘忠林 苏兴仁 |
| |
| 作者单位： | 沈阳药学院药理研究室，沈阳药学院药理研究室，沈阳药学院药理研究室，中国医科大学三院，中国医科大学三院，沈阳药学院药理研究室 |
| |
| 摘 要： | WB_(852)是我院药物合成研究室合成的环戊酮系列化合物之一。实验证明,WB_(852)对体外培养的L_(1210)细胞株及人早幼粒白血病细胞株有明显的抑制作用,对L_(1210)细胞在1μg/ml浓度时有明显的抑制作用,而对HL-60细胞在更低的浓度时就有明显的抑制作用。WB_(852)对小鼠移植性肿瘤有显著疗效,腹腔连续用药9天,对荷EAC和HepA小鼠的生命延长率分别为333%和149%;对B_(16)和Lewis肺癌的抑制率为92.8%和49.8%.WB_(852)腹腔连续用药7天对EAC细胞内cAMP和cGMP含量均无明显影响。
|
| 关 键 词： | WB_(852) 抗肿瘤作用 cAMP cGMP |
A STUDY ON ANTITUMOR ACTIVITY OF WB_(852) AND ITS EFFECTS ON cAMP AND cGMP CONTENT IN TUMOR CELLS |
| |
| Jing Yongkui Zhang Baofen Sun Jiantang Nie Lianzhi Liu Zhonglin Su Xingren Res,Dept. of Phar..A STUDY ON ANTITUMOR ACTIVITY OF WB_(852) AND ITS EFFECTS ON cAMP AND cGMP CONTENT IN TUMOR CELLS[J].Journal of Shenyang Pharmaceutical University,1992(3). |
| |
| Authors: | Jing Yongkui Zhang Baofen Sun Jiantang Nie Lianzhi Liu Zhonglin Su Xingren Res Dept of Phar |
| |
| Abstract: | WB_(852) has been found to have inhibitory effect on the growth of L_(1210) and HL-60 leukemia cells in vitro. WB_(852) prolonged the life span of EAC bearing mice and HepA-bearing mice, and inhibited the growth of B16 melanoma and Lewis lung tumor in mice. WB_(852) showed no effect on cAMP andc GMP levels in EAC cells. |
| |
| Keywords: | WB_(852) Antitumor effect cAMP cGMP |
| 本文献已被 CNKI 等数据库收录！ |
