氯吡格雷联合阿司匹林用于保守治疗非ST段抬高急性冠脉综合征的疗效观察

目的：探讨氯吡格雷联合阿司匹林治疗非ST段抬高急性冠脉综合征（ACS）患者的临床治疗效果。方法：选择本科住院施行保守治疗的不稳定心绞痛/非ST段升高的急性心肌梗塞患者122例,其中联合治疗组62例,对照组60例,所有患者均给予皮下注射低分子肝素连用8d,然后停用抗凝治疗。所有患者在继续接受包括阿司匹林（阿司匹林100m/d,首剂300mg）的标准治疗的同时,联合治疗组加用氯吡格雷（首剂300 mg,以后75mg/d）口服,连续给药至1年。结果：对两组患者进行比较,平均随访18个月,联合治疗组近期总心脏事件发生率为19.4%（12/62）;对照组为26.7%（16/60）。两组比较,差异有统计学意义（P〈0.05）。结论：氯吡格雷联合阿司匹林用于保守治疗非ST段抬高急性冠脉综合征的疗效好,总心脏事件发生率低。

Curative Effect Observation on the Conservative Treatment of Non-ST-segment Elevation in Acute Coronary Syndrome with Clopidogrel and Aspirin

Objective： To observe the efficacy of combination of clopidogrel and aspirin by oral in treatment of Non - ST - segment - elevation acute coronary syndrome. Method： 62 patients with ACS were selected as clopidogrel clinical trial group and 60 patients with ACS admitted at the same time were enrolled as control group. All patients in two groups subcutaneous injection low - molecular - weight heparin for 8 days. All patients in clopidogrel clinical trial group were treated with clopidogrel and aspirin 75mg by oral once a day for a course of 3 months. And the patients in control group were treated with aspirin 100mg by oral,once a day for a course of 1 year. Result ：The total cardiac events of clopidogrel clinical trial group and control group were 19.4% and 26.7% respectively. There was significant difference （ P 〈0.05 ）. Conclusion：The effectiveness of the conservative treatment in Non - ST - segment elevation ACS with clopidogrel and aspirin is definite.