过敏性紫癜患儿血清可溶性血管细胞黏附分子-1及可溶性细胞间黏附分子-1表达的意义

目的 检测过敏性紫癜(HSP)患儿血清可溶性血管细胞黏附分子-1(sVCAM-1)及可溶性细胞间黏附分子-1(sICAM-1)表达,并探讨其临床意义.方法 酶联免疫吸附法(ELISA)测定53例HSP患儿(其中急性期37例,恢复期16例)及25例健康儿童血清sVCAM-1、sICAM-1水平,分别比较其急性期和恢复期及有或无肾损害HSP患儿上述因子表达水平.结果 HSP急性期患儿血清sVCAM-1和sICAM-1水平明显高于恢复期和健康对照组(Pa＜0.01);肾损害组血清sVCAM-1、sICAM-1明显高于无肾损害组(Pa＜0.01).结论 sVCAM-1、sICAM-1参与HSP病理生理过程,与疾病分期相关;血清sVCAM-1、sICAM-1水平增高可作为儿童HSP肾损害的判断指标之一.

Significance of Expression of Serum Soluble Vascular Cell Adhesion Molecular and Soluble Intercellular Molecule-1 in Children with Henoch-Schoenlein Purpura

Objective To detect the levels of plasma soluble vascular cell adhesion molecular(sVCAM-1) and soluble intercellular mo-lecule-1(sICAM-1) in children with Henoch-Schoenlein purpura(HSP) and its clinical significance.Methods The plasma levels of sVCAM-1 and sICAM-1 were measured by enzyme-linked immunosorbent assay(ELISA) in 53 children with HSP(37 cases in acute stage and 16 cases in recovery stage)and in 25 healthy subjects respectively,and the change that in acute stage and recovery stage was analyzed,at the same time,the 2 factors in children with renal injury and without injury were analyzed.Results The serum levels of sVCAM-1 and sICAM-1 in acute stage HSP children were significantly higher than those in recovery stage and normal controls(Pa<0.01).Plasma levels of sVCAM-1 and sICAM-1 in children with renal injury were higher than those in children without(Pa<0.01).Conclusions These results suggest that sVCAM-1 and sICAM-1 participate in the pathogenesis of HSP.The increasing levels of these 2 molecules are correlated with renal injury in children with HSP.