| 肝细胞癌患者TACE介入治疗前后血清sICAM-1检测的临床意义 |
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| 引用本文： | 孙业全,李绪斌,许福亮,李公宝,纪恩美. 肝细胞癌患者TACE介入治疗前后血清sICAM-1检测的临床意义[J]. 潍坊医学院学报, 2005, 27(6): 428-430 |
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| 作者姓名： | 孙业全 李绪斌 许福亮 李公宝 纪恩美 |
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| 作者单位： | 潍坊医学院附属医院,山东,潍坊,261031 |
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| 摘 要： | 目的探讨肝细胞癌患者血清可溶性细胞间粘附分子-1(sICAM-1)在肝动脉栓塞化疗(TACE)介入治疗前、后水平的变化.方法肝细胞癌患者35例,健康人30例,采用酶联免疫吸附(ELISA)法,测定健康人及介入治疗前后的肝细胞癌患者血清sICAM-1水平.结果介入治疗前、后血清sICAM-1水平均显著高于正常人(P<0.05),肝细胞癌患者介入治疗前sICAM-1明显高于介入治疗后(P<0.05).结论 TACE可降低肝细胞癌患者血清sICAM-1的水平,提示检测血清sICAM-1有可能作为诊断肝细胞癌及评价其TACE疗效的一个新指标.
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| 关 键 词： | 肝肿瘤 血清可溶性细胞间粘附分子 酶联免疫吸附法 |
| 文章编号： | 1004-3101（2005）06-0428-03 |
| 收稿时间： | 2005-06-04 |
| 修稿时间： | 2005-06-04 |
The Clinical Significnace of Serum sICAM-1 Changes in Hepatocellular Carcinoma Patients Before and After Transcatheter Arterial Chemoembolization |
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| SUN Ye-quan,LI Xu-bin,XU Fu-liang,LI Gong-bao,JI En-mei. The Clinical Significnace of Serum sICAM-1 Changes in Hepatocellular Carcinoma Patients Before and After Transcatheter Arterial Chemoembolization[J]. Journal of Weifang Medical College, 2005, 27(6): 428-430 |
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| Authors: | SUN Ye-quan LI Xu-bin XU Fu-liang LI Gong-bao JI En-mei |
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| Affiliation: | The Affiliated Hospital of Weifang Medical College,Weifang 261031,China |
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| Abstract: | Objective To evaluate clinical significance of serum soluble intercellular adhesion molecule-1(sICAM-1) changes in hepatocellular carcinoma patients(HCC) receiving transcatheter arterial chemoembolization(TACE).Methods The serum levels of sICAM-1 in 35 cases of HCC before and after TACE and 30 normal controls were measured by enzyme-linked immunoadsorbent assay(ELISA)and compared.Results The sera levels of sICAM-1 in HCC group were higher than those in control group(P<0.05) and dropped down markedly after TACE(P<0.05).Conclusion The serum level of sICAM-1 can be reduced by TACE and may be used as a new marker of diagnosing HCC and evaluating effect of TACE in HCC patients. |
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| Keywords: | Liver neoplasm Soluble intercellular adhesion molecule-1 Enzyme-linked immunoadsorbent assay |
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