碳酸锂与丙基硫氧嘧啶对Graves病重型甲亢131碘疗效影响的比较

目的 比较碳酸锂与丙基硫氧嘧啶对Graves病重型甲亢的131碘（^131I）治疗效果的影响.方法 Graves病重型甲亢患者^131I治疗前为防止甲亢危象,一组采用碳酸锂联合治疗,每次口服量250mg,1日3次,持续5周,于开始服用碳酸锂2周后给予治疗量的^131I;一组使用丙基硫氧嘧啶联合治疗,每次口服量100mg,1日3次,余同前组,并于给^131I前后停药7 d.结果 碳酸锂组一次性治愈率明显高于丙基硫氧嘧啶组（P＜0.05）,而两组早发甲状腺功能减退发生率差异无显著性（P〉0.05）.结论Graves病重型甲亢患者^131I治疗前联合使用不同药物对^131I一次性治愈率有不同影响,^131I治疗前联合碳酸锂治疗的效果明显好于丙基硫氧嘧啶.

Comparative study on effect of lithium with PTU plus radioiodine treatment of severe hyperthyroidism

[Objective] To comparative study on effect of lithium carbonate with PTU plus radioiodine treatment of severe hyperthyroidism of Graves disease. [Methods] Patients with newly diagnosed, untreated severe hyperthyroidism, were randomly assigned to group 1 and group 2. The 1st group was treated with lithium carbonate plus radioiodine, the 2nd group with PTU plus radioiodine. effective rate and hypothyroid were observation and compared between two groups. [Results] Following up for 1 year. There was statistically significant different with regard to their results of cure rate (P <0.05). And there was not statistically significant different with regard to their results of hypothyroid (P >0.05). [Conclusion] The lithium carbonate method has such advantages as high effective rate.