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Thymidine labeling index in breast tumors
Authors:Hy De Lee Euy  Young Soh  Hoon Sang Chi  Byong Ro Kim  Kyong Sik Lee  Kyung Soon Song  Hyun Joo Jung
Affiliation:(1) The Department of Surgery, Yonsei University College of Medicine, 120-140 Seoul, Korea;(2) The Department of Clinical Pathology, Yonsei University College of Medicine, 120-140 Seoul, Korea;(3) The Department of Pathology, Yonsei University College of Medicine, 120-140 Seoul, Korea
Abstract:The relationship between primary tumor proliferative activity and clinical and pathologic characteristics was analyzed in relation to menopausal status in 32 patients with malignant or benign breast disease. The thymidine labeling index (TLI) showed significantly higher median values in the cancer patients (3.48 per cent) than in the patients with benign diseases (1.02 per cent). TLI was not significantly affected by delayed incubation at room temperature for about 1 hour. In the breast cancer patients, TLI did not significantly correlate to tumor size, the presence of axillary lymph node metastasis or pathologic nuclear grading. The only significant difference was limited to the breast cancer patients without axillary lymph node metastasis in relation to menopausal status; the TLI in the premenopausal patients (5.10 per cent) was significantly higher (p<0.05) than that in the postmenopausal patients (2.28 per cent). These data thus suggest that among premenopausal patients without axillary lymph node metastasis, those with a high TLI could be potential candidates for adjuvant chemotherapy.
Keywords:thymidine labeling index  breast cancer  menopausal status
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