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The potential role of statins in preeclampsia and dyslipidemia during gestation: a narrative review |
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| Authors: | Serban M. Maierean Dimitri P. Mikhailidis Peter P. Toth Mariusz Grzesiak Moshen Mazidi Marek Maciejewski |
| Affiliation: | 1. “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania;2. Department of Clinical Biochemistry, University College London Medical School, University College London (UCL), London, UK;3. Department of Preventive Cardiology, CGH Medical Center, Sterling, IL, USA;4. Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA;5. Department of Gynecology and Obstetrics, Polish Mother’s Memorial Hospital Research Institute, Lodz, Poland;6. Department of Biology and Biological Engineering, Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden;7. Department of Cardiology, Chair of Cardiology and Cardiac Surgery Medical University of Lodz, Lodz, Poland |
| Abstract: | Introduction: Statins have several pleiotropic effects that have the potential to be beneficial during pregnancy. This study evaluates the available evidence for the teratogenicity of statins, and their utility in treating preeclampsia and dyslipidemia in pregnancy, as good alternatives in these domains are currently lacking. Areas covered: The possible teratogenicity of statins is a primary focus of this paper. We also evaluated for some possible non-teratogenic effects, such as changes in birth weight and rates of spontaneous abortion, among mothers exposed to statins during pregnancy. Regarding potential uses, this study mainly discusses statin utility in preventing and treating preeclampsia and treating dyslipidemia in pregnancy. Within the latter, we explore the relationship between dyslipidemia and preeclampsia, the potential consequences of delaying statin therapy where indicated, and the impact of supra-physiological levels of cholesterol in utero on offspring. The literature search was conducted using Embase, Web of Science, PubMed, and Scopus. Expert opinion: Based on current evidence, statins are likely not teratogenic. Limited, but promising evidence exists for their efficacy in treating and preventing preeclampsia. In utero exposure to high cholesterol may negatively impact offspring, and should be thoroughly investigated. |
| Keywords: | Statins preeclampsia teratogenesis pregnancy dyslipidemia |