有下尿路症状的前列腺增生人群临床症状参数与血清PSA值之间的关系

目的:探讨有下尿路症状(LUTS)的前列腺增生(BPH)人群年龄、前列腺体积、残余尿、国际前列腺症状评分(IPSS)、最大尿流率对血清前列腺特异性抗原(PSA)值的影响,寻找影响血清PSA值的最主要因素。方法:应用酶联免疫法测定了191例51～81岁有LUTS的BPH人群血清总前列腺特异性抗原(TPSA)、游离前列腺特异性抗原(FPSA)值。应用直线相关统计学方法分析年龄、前列腺体积、残余尿、IPSS评分、最大尿流率与血清PSA值的相关性。结果:年龄与TPSA、FPSA、前列腺特异抗原密度(PSAD)成正相关关系(P<0.05);与FPSA/TPSA无相关性(P>0.05)。前列腺体积与TPSA、FPSA呈强正相关关系(P<0.01);与FPSA/TPSA值呈弱负相关关系(P<0.05)。残余尿量、IPSS评分与血清TPSA值呈弱正相关关系(P<0.05)。最大尿流率和血清TPSA值有弱负相关关系(P<0.05)。多元线性回归分析得出只有前列腺体积与血清PSA值有相关性(P<0.01),其他因素与血清PSA值之间均没有相关性(P>0.05)。结论:前列腺体积是导致血清PSA值变化的最主要因素。

Relationship between prostatic specific antigen and clinical symptomatic parameters in benign prostatic hyperplasia with lower urinary tract symptoms

Objective： To evaluate the relationship between age, prostate volume, post-void residual urine, flow rate, international prostatic symptom score and serum prostatic specific antigen ,and explore the most affected reason on serum PSA. Methods： Serum tPSA and fPSA were measured by enzyme linked immunosorbent assay （ELISA） in 191 BPH patients of 23-85 years old with LUTS The relationship between age,PV,PVR,IPSS,Qmax and PSA indexes was analyzed with simple linear regression1. Results： Age and tPSA,fPSA,PSAD had a positive liner relationship （P〈0. 05） ;age had no correlation with FPSA / TPSA（P〉0.05）. PV had strong positive correlation with TPSA and FPSA（P〈0. 01） ;there was weak negative correlation between PV and F/T（P〈0.05） . PVR and IPSS had weak positive correlation with tPSA . There was weak negative correlation between Qmax and tPSA （P〈0.05）. Multiple linear regession analyses showed that only PV had correlation with PSA （P〈0.01）. Conclusion： The PV might be the principal reason of PSA increase.