有下尿路症状的前列腺增生人群临床症状参数与血清PSA值之间的关系 |
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引用本文: | 屈卫星,贺大林,王明珠,何辉,王新阳. 有下尿路症状的前列腺增生人群临床症状参数与血清PSA值之间的关系[J]. 陕西医学杂志, 2009, 38(5): 577-579 |
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作者姓名: | 屈卫星 贺大林 王明珠 何辉 王新阳 |
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作者单位: | 西安交通大学医学院第一附属医院泌尿外科,西安,710061 |
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摘 要: | 目的:探讨有下尿路症状(LUTS)的前列腺增生(BPH)人群年龄、前列腺体积、残余尿、国际前列腺症状评分(IPSS)、最大尿流率对血清前列腺特异性抗原(PSA)值的影响,寻找影响血清PSA值的最主要因素。方法:应用酶联免疫法测定了191例51~81岁有LUTS的BPH人群血清总前列腺特异性抗原(TPSA)、游离前列腺特异性抗原(FPSA)值。应用直线相关统计学方法分析年龄、前列腺体积、残余尿、IPSS评分、最大尿流率与血清PSA值的相关性。结果:年龄与TPSA、FPSA、前列腺特异抗原密度(PSAD)成正相关关系(P<0.05);与FPSA/TPSA无相关性(P>0.05)。前列腺体积与TPSA、FPSA呈强正相关关系(P<0.01);与FPSA/TPSA值呈弱负相关关系(P<0.05)。残余尿量、IPSS评分与血清TPSA值呈弱正相关关系(P<0.05)。最大尿流率和血清TPSA值有弱负相关关系(P<0.05)。多元线性回归分析得出只有前列腺体积与血清PSA值有相关性(P<0.01),其他因素与血清PSA值之间均没有相关性(P>0.05)。结论:前列腺体积是导致血清PSA值变化的最主要因素。
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关 键 词: | 前列腺增生/诊断 前列腺特异性抗原 尿动力学 |
Relationship between prostatic specific antigen and clinical symptomatic parameters in benign prostatic hyperplasia with lower urinary tract symptoms |
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Affiliation: | Qu Weixing He Dalin Wang Mingzhu et al(Department of Urology , the First Affiliated Hospital ,Medical College of Xi'an Jaotong University Xi'an 710061) |
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Abstract: | Objective: To evaluate the relationship between age, prostate volume, post-void residual urine, flow rate, international prostatic symptom score and serum prostatic specific antigen ,and explore the most affected reason on serum PSA. Methods: Serum tPSA and fPSA were measured by enzyme linked immunosorbent assay (ELISA) in 191 BPH patients of 23-85 years old with LUTS The relationship between age,PV,PVR,IPSS,Qmax and PSA indexes was analyzed with simple linear regression1. Results: Age and tPSA,fPSA,PSAD had a positive liner relationship (P〈0. 05) ;age had no correlation with FPSA / TPSA(P〉0.05). PV had strong positive correlation with TPSA and FPSA(P〈0. 01) ;there was weak negative correlation between PV and F/T(P〈0.05) . PVR and IPSS had weak positive correlation with tPSA . There was weak negative correlation between Qmax and tPSA (P〈0.05). Multiple linear regession analyses showed that only PV had correlation with PSA (P〈0.01). Conclusion: The PV might be the principal reason of PSA increase. |
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Keywords: | Benign prostate hyperplasia/diagnosis Prostate specific antigen Urodynamics |
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