| 国产新药和福喷丁在人体内药代动力学研究 |
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| 引用本文： | 方治平,王浴生,杨芳炬,孔古娅,徐金枝.国产新药和福喷丁在人体内药代动力学研究[J].中国药理学通报,1989(1). |
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| 作者姓名： | 方治平 王浴生 杨芳炬 孔古娅 徐金枝 |
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| 作者单位： | 华西医科大学药理教研室，华西医科大学药理教研室，华西医科大学药理教研室，华西医科大学药理教研室，四川抗菌素研究所 成都，成都，成都，成都 |
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| 摘 要： | 9名志愿受试者口服利福喷丁(Rifapentine)连续给药10d,随后改为每周两次的间隙给药连续3周的药代动力学研究结果,与利福定作比较。发现利福喷丁吸收、排泄均较利福定慢,在体内维持时间长,T1/2为15h。连服药10d,血中药浓先是逐渐上升,4、5d达到最高,随后下降,这可能与利福霉素激活肝药酶有关。
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| 关 键 词： | 利福喷丁 利福定 半衰期 肝药酶 药代动力学 |
STUDY ON THE PHARMACOKINETIC OF RIFAPENTINE IN VOLUNTEERS |
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| Fang Zhiping,Wang Yusheng Yang Fangju et.STUDY ON THE PHARMACOKINETIC OF RIFAPENTINE IN VOLUNTEERS[J].Chinese Pharmacological Bulletin,1989(1). |
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| Authors: | Fang Zhiping Wang Yusheng Yang Fangju et |
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| Abstract: | The pharmacokinetic study of Rifapentine by daily oral administration for 10d and followed by twice weekly for another 3 weeks in 9 volunteers and in comparism with Rifandin were reported. The results showed that the absorption and excretion of Rifapentine were markedly slower than that of Rifandin, its T1/2 was 15h. The Peak plasma level and T1/2 decreased after repeated administration of the drug. This suggested that Rifapentine and Rifandin in similar to Ri-fampin were hepatic microsomal enzyme inducers. |
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| Keywords: | Rifapentine Rifandin Plasma half life Pharmacokinetic Hepatic microsomal enzyme |
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