2.5%碳酸氢钠溶液行口腔冲洗预防ICU呼吸机相关性肺炎的临床研究

目的 探讨经口气管插管危重患者口腔护理方法,以减少口腔感染,减少口腔定植菌,切断胃-口腔-肺感染途径,减少呼吸机相关性肺炎.方法 采用前瞻性队列研究,按随机数字将受试对象分实验组和对照组.实验组每天采用2.5%碳酸氢钠溶液行口腔擦洗加冲洗,每天3次,对照组用生理盐水棉球行口腔擦洗,两组均在口腔护理前后测定pH值,48 h后行痰培养及口腔定植菌监测,分析两组患者呼吸机相关性肺炎(VAP)发生率、病原学检测结果.结果 实验组呼吸机相关性肺炎发生率降低(P<0.05),真菌感染率明显降低,口腔定植菌减少.结论 采用2.5%碳酸氢钠溶液行口腔冲洗可有效减少口腔定植菌,降低呼吸机相关性肺炎发生率.

2.5% sodium bicarbonate solution line oral prevention ICU ventilator-associated pneumonia

Objective To discuss the effective oral nursing methods of critically ill patients with orotracheal intubatton in order to reduce oral infection,reduce oral colonization,cut off the stomach-oral-pulmonary infection route,and reduce the number of ventilator-associated pneumonia.Methods Research methods for prospective cohort study.According to the random number will be subject,the cases were divided into experimental group and control group.Experimental group was given 2.5% sodium bicarbonate solution line cleaning,washing and rinsing the oral cavity,three times a day.The control group was given normal saline line cleaning,washing,cotton mouth.Two groups were made at the oral care before and after determination of the pH value after 48 hours.Sicksinus sputum culture and oral monitoring colonization were analyzed of two sets of ventilator-associated pneumonia (VAP) incidence..Results The incidence of ventilator-associated pneumonia in experimental group was reduced (P<0.05>,and the fungal infection rate was significantly decreased..Conclusions With 2.5% sodium bicarbonate solution line of oral rinse can effectively reduce oral colonization and decrease the incidence of ventilator-associated pneumonia.