TRANSSYNAPTIC DEGENERATION IN THE INFERIOR OLIVARY NUCLEUS ASSOCIATED WITH PONTINE GLIOBLASTOMA |
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| Authors: | Yasuhiro Nakamura Tomohiko Sato Tatsuo Tanaka Toshihiko Kinjyo Akira Tanimura Kazuhiko Nagayama Toyohide Yanai Kozue Masaike Noriko Sibao |
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| Institution: | Second Department of Pathology. Kurume University School of Medicine, Kurume; Department of Neurosurgery, Almeida Memorial Hospital, Oita; Department of Pathology, Almeida Memorial Hospital, Oita |
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| Abstract: | A case of glioblastoma arising in the pons of a 14-year-old boy in whom transsynaptic degeneration was found in the inferior olivary nucleus is reported. The tumor occupied most of the pons including the tegmental tract and invaded into the midbrain, medulla oblongata, cerebellar peduncles, thalamus, basal ganglia, and meninges. The right inferior olivary nucleus was devoid of the tumorous lesion, but many neurons were severely vacuolated. An im-munohistochemical study using glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE), and S-100 protein was performed. GFAP and S-100 protein were positive in the reactive glia of the nucleus and NSE gave a faint reaction in some degenerated neurons. These degenerative changes found in neurons of the inferior olivary nucleus were considered to be transsynaptic degeneration due to the destruction of the tegmental tract at the pons and of cerebellar peduncles by invasive pontine glioblastoma. ACTA PATHOL. JPN. 35: 1495–1500, 1985. |
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