| 高效液相色谱法测定马拉韦罗片的含量 |
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| 引用本文： | 张霞. 高效液相色谱法测定马拉韦罗片的含量[J]. 中国新药与临床杂志, 2012, 0(2): 110-112 |
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| 作者姓名： | 张霞 |
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| 作者单位： | 临淄区人民医院药剂科 |
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| 摘 要： | 目的建立高效液相色谱法测定马拉韦罗片的含量。方法色谱柱:Shimadzu C18柱(250 mm×4.6 mm,5μm),流动相:乙腈-0.01 mol.L-1磷酸二氢钾溶液(25∶75,V/V),柱温:(35.0±1.0)℃,流速:1.0 mL.min-1,检测波长:197 nm。结果马拉韦罗的线性范围为0.1～0.5 g.L-1(r=0.999 7),平均回收率为(99.83±0.60)%(n=9)。结论本方法简便、准确,可用于马拉韦罗片的含量测定。
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| 关 键 词： | 马拉韦罗 含量 色谱法,高压液相 |
Determination of maraviroc tablets by high performance liquid chromatography |
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| ZHANG Xia. Determination of maraviroc tablets by high performance liquid chromatography[J]. Chinese Journal of New Drugs and Clinical Remedies, 2012, 0(2): 110-112 |
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| Authors: | ZHANG Xia |
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| Affiliation: | ZHANG Xia(Pharmacy Department of the People’s Hospital of Linzi District,Zibo SHANGDONG 255400,China) |
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| Abstract: | AIM To establish a method for content determination of maraviroc tablets by high performance liquid chromatography.METHODS A Shimadzu C18 column(250 mm × 4.6 mm,5 μm)was used with the mobile phase of acetonitrile-0.01 mol·L-1 potassium dihydrogen orthophosphate solution(25:75,V/V).Column temperature was(35.0 ± 1.0)℃.Flow rate was 1.0 mL·min-1.UV detection wave length was 197 nm.RESULTS The linear range of maraviroc tablets was 0.1-0.5 g·L-1(r = 0.999 7),with average recovery was(99.83 ± 0.60)%(n = 9).CONCLUSION The established method is simple,accurate and suitable for the quality control of maraviroc tablets. |
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| Keywords: | maraviroc content chromatography,high pressure liquid |
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