血管性痴呆患者血清CGRP、NPY水平的变化及意义

目的探讨血管性痴呆(VD)患者血清中降钙素基因相关肽(CGRP)及神经肽Y(NPY)水平的变化及其意义。方法测定VD组、脑梗死非痴呆组(CI组)、健康对照组(NC组)血清CGRP及神经肽NPY水平变化,分析与蒙特利尔认知评估量表(MoCA)评分的关系。结果 VD组MoCA评分、CGRP水平低于NC组和CI组,NPY水平高于NC组和CI组,差异均有统计学意义(P<0.05)。VD组的MoCA评分与血清CGRP水平呈正相关(r=0.439,P<0.01),与血清NPY水平呈负相关(r=-0.278,P<0.05)。结论脑的长期慢性低灌注是VD发生发展的主要危险因素。脑血管舒缩功能平衡失调既可能是脑缺血缺氧的结果,又可能是进一步导致脑细胞损伤的重要原因。

Correlation among CGRP and NPY of patients with vascular dementia

Objective To investigate the effect of serum level of calcitonin gene-related peptide(CGRP)and neuropeptide Y(NPY)and their significance in patients of vascular dementia(VD).Methods The change of levels of CGRP and NPY in VD group,non-infarct dementia group(CI group),and healthy control group(NC group)was measured.The scores of Montreal Cognitive Assessment Scale(MoCA)of groups were compared.Results In VD group,MoCA score and CGRP levels were lower than the NC group and CI group,while NPY levels were higher than two groups,and the differences were statistically significant(P<0.05).MoCA score and CGRP levels were positively correlated(r=0.439,P<0.01),and NPY levels were negatively correlated(r =-0.278,P<0.05)in VD group.Conclusion Chronic brain hypoperfusion is the major risk factors for VD.Vasomotor imbalance of brain function can be a result of cerebral ischemia and hypoxia,and may lead to damage of brain cell further.