细胞周期素B1在大肠癌中的表达及意义

目的 为探讨细胞周期素B1（cyclin B1）在大肠癌中的表达、临床意义.方法 收集80例手术切除的大肠癌标本,同时取距癌灶5cm以外的癌旁组织及10cm以外的正常组织,采用免疫组化SP法检测癌组织、癌旁组织及正常组织中cyclinB1的表达.结果 80例标本癌组织中cyclin B1过表达率为55.0%;癌旁组织为2.5%;正常大肠组织中未见cyclin B1过表达,癌组织中cyclin B1的过表达率与正常组织及癌旁组织有显著性差异（P＜0.01）.cyclin B1的过表达与患者年龄、肿瘤大小、组织学类型之间存在显著性差异（P＜0.05）.结论 cyclin B1的过表达可能是大肠癌发生的早期事件,针对抑制cyclin B1表达的措施可能成为治疗早期大肠癌的重要手段之一.

Overexpression of cyclin B1 and its significance in colorectal carcinoma

Objective To investigate the expression of cyclinB_1 and its clinical significance in colorectal carcinoma. Methods 80 specimens surgically resected from patients with colorectal carcinoma were collected. Then the expression of cyclin B_1 in colorectal carcinoma, para-carcinoma and normal tissue were detected by SP immunohistochemical method. Results The positive rates of cyclin B_1 overexpression in colorectal carcinoma, paracarcinoma and nomal tissue were 55.0%,2.5% and 0% respectively. There was significant difference of cyclinB_1's overexpression between the colorectal carcinoma and nomal tissue or between the colorectal carcinoma and the colorectal pericacinoma (P<0.01). Overexpression of cyclin B_1 was correlated with patient's age, diameter of carcinoma, differentiated degree(P<0.05). Conclusion Overexpression of cyclin B_1 occurs in the early stage of colorectal carcinomatous change and suppression of overexpression of the cyclin B_1 may be an important method for the therapy in the early stage of colorectal carcinoma.