| N-取代-5-羟基-1H吲哚-3-羧酸酯类衍生物的合成 |
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| 引用本文： | 宋艳玲,赵燕芳,宫平.N-取代-5-羟基-1H吲哚-3-羧酸酯类衍生物的合成[J].中国新药杂志,2004,13(4):335-337. |
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| 作者姓名： | 宋艳玲 赵燕芳 宫平 |
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| 作者单位： | 1. 沈阳化工学院制药工程教研室,沈阳,110142
2. 沈阳药科大学制药工程学院,沈阳,110016 |
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| 摘 要： | 目的:以阿比朵尔为先导化合物,设计并合成一系列4-取代胺甲基-5-羟基-1-烃基-2-苯硫基甲基-1H吲哚-3-羧酸乙酯盐酸盐.方法:以4-氯代乙酰乙酸乙酯为起始原料通过硫代、胺化、Nenitzescu反应、Mannich反应、成盐反应共5步反应制得目标产物.由薄层色谱(TLC)确定每步反应终点.结果:目标化合物结构经红外光谱、核磁共振光谱及质谱确证.结论:通过该合成方法合成了9个未见报道的新化合物.
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| 关 键 词： | 阿比朵尔 N-取代-5-羟基-1H吲哚-3-羧酸酯类衍生物 药物合成 |
| 文章编号： | 1003-3734(2004)04-0335-03 |
Synthesis of derivatives of N-alkyl-5-hydroxy-1H-indole-3-carboxylic ester hydrochloride |
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| SONG Yan-ling,ZHAO Yan-fang,GONG Ping.Synthesis of derivatives of N-alkyl-5-hydroxy-1H-indole-3-carboxylic ester hydrochloride[J].Chinese Journal of New Drugs,2004,13(4):335-337. |
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| Authors: | SONG Yan-ling ZHAO Yan-fang GONG Ping |
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| Abstract: | Objective: To synthesize some derivatives of N-alkyl-5-hydroxy-lH-indole-3-car-boxylic ester hydrochloride using arbidol as leading compound. Methods: Using 4-chloroethyl acetoac-tate as starting material, the target compounds were synthesized through 5 unite reactions, including sulfurizing,amination,Nenitzescu reaction, Mannich reaction and salt formation. The end up of reaction was determined by TLC. Results: The chemical structure of these target compounds were confirmed by IR,1H-NMR and MS. Conclusion: 9 unreported derivatives of N-alkyl-5-hydroxy-1H-in-dole-3-carboxylic ester hydrochloride were synthesized by this way. |
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| Keywords: | arbidol N-alkyl-5-hydroxy-1H-indole-3-carboxylic ester hydrochloride synthesis |
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