Cerebral cystine uptake: a tale of two transporters |
| |
Authors: | McBean Gethin J |
| |
Institution: | Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. Gethin.McBean@ucd.ie |
| |
Abstract: | Transport of cystine across the cell membrane is essential for synthesis of the major cellular antioxidant glutathione. Cystine uptake in the brain occurs by both the Na(+)-independent x(c)(-) cystine-glutamate exchanger and the X(AG)(-) family of high-affinity, Na(+)-dependent glutamate transporters. New evidence concerning the role of cystine transport in the defence against oxidative stress is described. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|