| HPLC法测定胃健宁胶囊中和厚朴酚及厚朴酚的含量 |
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| 引用本文： | 叶锦雄,刘柳毅. HPLC法测定胃健宁胶囊中和厚朴酚及厚朴酚的含量[J]. 齐鲁药事, 2014, 0(4): 203-205 |
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| 作者姓名： | 叶锦雄 刘柳毅 |
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| 作者单位： | [1]广州市东升医院,广东广州510140 [2]广州中医药大学中药学院,广东广州510006 |
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| 摘 要： | 目的建立胃健宁胶囊中和厚朴酚及厚朴酚的检测方法。方法色谱条件为C18色谱柱;流动相:乙腈-水-冰醋酸(60∶40∶1)(V∶V∶V);流速:1.000 mL·min-1;检测波长:294 nm。结果胃健宁胶囊中和厚朴酚在0.020.32μg(r=0.999 6)范围内线性关系良好,平均回收率为96.58%,RSD为1.78%(n=9);厚朴酚在0.019 60.32μg(r=0.999 6)范围内线性关系良好,平均回收率为96.58%,RSD为1.78%(n=9);厚朴酚在0.019 60.313 6μg(r=0.999 8)范围内线性关系良好,厚朴酚的平均回收率为97.29%,RSD为1.39%(n=9)。结论该方法简便,准确度高,可有效控制胃健宁胶囊的质量。
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| 关 键 词： | 胃健宁胶囊 和厚朴酚 厚朴酚 高效液相色谱法 |
Determination of honokiol and magnolol in Weijianning Capsules by HPLC |
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| YE Jin-xiong,LIU Liu-yi. Determination of honokiol and magnolol in Weijianning Capsules by HPLC[J]. qilu pharmaceutical affairs, 2014, 0(4): 203-205 |
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| Authors: | YE Jin-xiong LIU Liu-yi |
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| Affiliation: | 1. Guangzhou Dongsheng Hospital,Guangzhou 510140,China ;2. College of Traditional Chinese Medicine Guangzhou University of Traditional Chinese Medicine, Guangzhou 510006, China ) |
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| Abstract: | Objective To establish an HPLC method for the determination of honokiol and magnolol in Weijianning Cap- sules. Methods The separation was performed on the Cm column with acetonitrile -water- acetic acid（60：40：l ） （V：V：V） as the mobile phase. The flow rate was 1. 000 mL ·min~（-1）. The detection wavelength was 294 nm. Results There was good linearity between the peak areas and concentrations in the range of 0. 02 -0. 32 μg（ r =0. 999 6）for honokiol and 0. 019 6 ~ 0. 313 6 μg（r = 0. 999 8）for magnolol,respectively. The average recovery rates of honokiol and magnolol were 96. 58% ,RSD was 1.78% （ n = 9 ） and 97. 29% , RSD was 1.39% （ n = 9 ） , respectively. Conclusion This method was simple and reliable, it can be used for the quality control of Weijianning Capsules. |
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| Keywords: | Weijianning Capsules Honokiol Magnolol HPLC |
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