29例中线恶性网状细胞增多症的病理及免疫组化观察

本文报告29例中线恶性网状细胞增多症,着重对临床、病理形态及,免疫组化观察进行探讨.病理诊断依据是:1、有显著的坏死.2、炎性浸润及异形淋巴细胞(ALC)浸润,并浸润粘膜上皮及缸管壁.3、ALC 的形态分大、中、小3型,数量随临床分期而变化.免疫组化标记结果,病变组织中 ALC 呈 UCHL_1,LCA 膜阳性反应,而 K、λ、Mac_(387)、Lysozymc 均呈阴性反应,提示是 T 细胞来源的恶性淋巴瘤.

PATHOMORPHOLOGIC AND IMMUNOHISTOCHEMICAL OBSERVATION OF MIDLINE MALIGNANT RETICULOSIS OF 29CASES

In this paper 29 cases of midline malignant reticulosis (MMR) are reported.The enphasis is put on the clinical,histopathologic and immunohistochcmical observation.The pathologic diagnosis was based on the following:1.the significant necrobiosis,2.The infiltration of inflammation and atypical lymphoid cell (ALC),3.the infiltration of ALC onto the mucosa of epithelial and vascular wall.Accordign to the size,ALC were divided into three subtypes:the large,intermediate and small groups.Their amount of ALC changed with the clinical stage.The result of immunohistochemical study showed that UCHL and LCA reactions were positive,while K,λ,Mac_(387)and lysozyme reaction negatiae.It indicates that ALC of MMR belong to one kind of T-cell origin lymphoma.