白细胞介素10和C反应蛋白在急性胰腺炎患者血清中的变化

目的：研究急性胰腺炎（acute pancreatitis,AP）患者血清中白细胞介素10（IL-10）和C反应蛋白（CRP）与AP严重程度的关系及临床意义。方法：应用ELISA法检测12例健康人和45例AP患者发病后第1、2、3、4和5天血清IL-10、CRP浓度。结果：健康对照组血清中未检出IL-10。AP患者血清中IL-10于发病第1天升高，2～5 d逐渐降低，且发病第1天轻型胰腺炎（MAP）组 IL-10血清浓度明显高于重型胰腺炎（SAP）组，第2～5天两组间差异无显著性，MAP发病第1天 IL-10浓度明显高于第2、3、4、5天（P<0.01），SAP发病第1~3天IL-10浓度明显高于第4、5天（P<0.05），不同病因所致的AP，或伴发胰腺坏死与液体聚集时，血清IL-10和CRP活性差异无显著性。结论：AP患者血清IL-10在发病早期有其变化规律，可用于早期辅助诊断，尤以发病第1天血清IL-10水平有利于MAP与SAP的鉴别。外源性IL-10可能成为治疗早期AP的一种有效方法，联合检测IL-10、CRP可作为急性胰腺炎判断预后的指标之一。

Changes of serum interleukin-10 and C-reactive protein in patients with acute pancreatitis

Objective To evaluate the relationship between serum IL-10 and c-reactive protein (CRP) in patients with acute pancreatitis (AP) and the severity of AP and its clinical significance.Methods The levels of serum IL-10 and CRP were determined by ELISA in 12 healthy subjects and 45 patients with AP on the 1st,2nd,3rd,4th and 5th days after onset.Results The serum IL-10 was not found in control group. The levels of serum IL-10 was increased on the 1st day of onset, then was decreased. The level of IL-10 in patients with mild acute pancreatitis (MAP) was significantly higher than that in patients with severe acute pancreatitis (SAP) on the 1st day of onset; the levels of serum IL-10 was hgihest in patients with MAP on the 1st day of onset;it was higher in patients with SAP on the 1st,2nd and 3rd days than that on the 4th and 5th days (P<0.05).Conclusion The change of serum IL-10 in patients with AP may be used as early accessory diagnosis of AP. The level of serum IL-10 on the 1st day of onset may be used to identify MAP and SAP. The combinated determine of IL-10 and CRP may be used as one index to judge the prognosis.