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| D-氨基葡萄糖盐酸盐激活Ca2+信号通路诱导淋巴细胞增殖 | |
| 引用本文： | 曹秀明,李惠,张珍珠,刘万顺. D-氨基葡萄糖盐酸盐激活Ca2+信号通路诱导淋巴细胞增殖[J]. 中国海洋药物, 2007, 26(6): 17-19 |
| 作者姓名： | 曹秀明 李惠 张珍珠 刘万顺 |
| 作者单位： | 1. 哈尔滨商业大学药物所,黑龙江,哈尔滨,150076;中国海洋大学生命学院,山东,青岛,266003 2. 哈尔滨商业大学药物所,黑龙江,哈尔滨,150076 3. 中国海洋大学生命学院,山东,青岛,266003 |
| 基金项目： | 黑龙江省科技厅青年基金(No．QC04C36) |
| 摘 要： | 目的研究D-氨基葡萄糖盐酸盐(GAH)诱导小鼠脾淋巴细胞增殖及其机制。方法采用MTT法、荧光探针标记法、免疫荧光法观察GAH对淋巴细胞增殖、淋巴细胞内的钙离子浓度、调神经磷酸酶表达的影响。结果GAH能够诱导小鼠淋巴细胞增殖,提高淋巴细胞内钙离子浓度,增强钙调神经磷酸酶的表达。结论GAH通过提高淋巴细胞内钙离子浓度,增加钙调神经磷酸酶的表达,激活淋巴细胞的Ca2 信号通路,诱导淋巴细胞增殖。 |
| 关 键 词： | D-氨基葡萄糖盐酸盐 淋巴细胞增殖 细胞内钙浓度 钙调神经磷酸酶 |
| 文章编号： | 1002-3461（2007）06-0017-03 |
| 收稿时间： | 2007-04-01 |
D-glucosamine hydrochloride (GAH) induce lymphocyte proliferation through Ca2+ signal pathway |
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| CAO Xiu-ming,LI Hui,ZHANG Zhen-zhu,LIU Wan-shun. D-glucosamine hydrochloride (GAH) induce lymphocyte proliferation through Ca2+ signal pathway[J]. Chinese Journal of Marine Drugs, 2007, 26(6): 17-19 | |
| Authors: | CAO Xiu-ming LI Hui ZHANG Zhen-zhu LIU Wan-shun |
| Abstract: | Objective To study the effect of GAH on lymphocytes proliferation and its mechanism. Methods MTT, fluorescence probe and immunofluorescent methods were used to investigate the effects of GAH on the lymphocytes proliferation, intracelluar Ca2 concentration and expression of calcineurin(CaN). Results GHA induced lymphocyte proliferation, raised the intracelluar Ca2 concentration and calcineurin expression. Conclusions GAH is a new kind of activator, which can induce lymphocyte proliferation through Ca2 signal pathway. |
| Keywords: | D-glucosamine hydrochloride lymphocytes proliferation intracellular calcium concentration calcineurin |
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