| CD44v6和Smad7在卵巢子宫内膜异位症中的表达及其意义 |
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| 引用本文： | 夏晓梦,邵文静,方小玲. CD44v6和Smad7在卵巢子宫内膜异位症中的表达及其意义[J]. 中国现代医学杂志, 2011, 21(13) |
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| 作者姓名： | 夏晓梦 邵文静 方小玲 |
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| 作者单位： | 1. 中南大学湘雅二医院,妇产科,湖南,长沙,410011
2. 吉林大学第一医院,妇产科,吉林,长春,130000 |
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| 摘 要： | 目的 研究卵巢子宫内膜异位症患者在位内膜和异位内膜组织中CD44v6和Smad7的表达及其意义.方法 用免疫组化SABC法检测卵巢子宫内膜异住症30例卵巢异位内膜、25例在位内膜、30例正常内膜中CD44v6和Smad7的表达.结果 CD44v6在异位内膜中表达明显高于在位内膜、正常内膜(P<0.05),在位内膜组、正常内膜组分泌期内膜CD44v6表达明显高于增生期内膜(P<0.05);Smad7在异位及在位内膜中表达明显低于正常内膜(P<0.05),在位内膜组、正常内膜组分泌期内膜Smad7与增生期内膜比较差异无统计学意义(P>0.05);二者在卵巢子宫内膜异位症中的表达相关性无统计学意义(P>0.05).结论 CD44v6和Smad7在卵巢子宫内膜异位症中异常表达,在卵巢子宫内膜异位症的发生发展中可能起着重要的作用.
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| 关 键 词： | 子宫内膜异住症 CD44v6 Smad7 免疫组织化学 |
Expression of CD44v6 and Smad7 in ovarian endometriosis and its significance |
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| XIA Xiao-meng , SHAO Wen-jing , FANG Xiao-ling. Expression of CD44v6 and Smad7 in ovarian endometriosis and its significance[J]. China Journal of Modern Medicine, 2011, 21(13) |
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| Authors: | XIA Xiao-meng SHAO Wen-jing FANG Xiao-ling |
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| Affiliation: | XIA Xiao-meng1,SHAO Wen-jing2,FANG Xiao-ling1(1.Department of Gynecology and Obstetrics,Second Xiangya Hospital,Central South University,Changsha,Hunan 410011,P.R.China,2.Department of Gynecology and Obstetrics,the First Hospital of Jilin University,Changchun,Jilin 130000,P.R.China) |
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| Abstract: | Objective To investigate the expression CD44v6 and Smad7 in endometriosis and the role of CD44v6 and Smad7 in the pathogenesis of endometriosis.Methods The expressions of CD44v6 and Smad7 were detected with immunohistochemiscal technic in 30 cases of ovarian endometriotic tissues and 25 cases eutopic endometrium tissues with endometriosis and 30 cases of normal endometriums without endometriosis.Results The CD44v6 expression of ectopic endometrium group was higher than that of eutopic endometrium group and ... |
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| Keywords: | endometriosis CD44v6 Smad7 immunohistochemistry |
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