| 东亚钳蝎蝎毒二、三级提取物对快反应心肌细胞动作电位的影响 |
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| 引用本文： | 江岩,刘伟,钟国赣,杨世杰,张文杰,魏俊杰,张红军,王琳. 东亚钳蝎蝎毒二、三级提取物对快反应心肌细胞动作电位的影响[J]. Acta pharmacologica Sinica, 1995, 0(2) |
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| 作者姓名： | 江岩 刘伟 钟国赣 杨世杰 张文杰 魏俊杰 张红军 王琳 |
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| 作者单位： | 白求恩医科大学生理中心实验室，白求恩医科大学生理中心实验室，白求恩医科大学生理教研室，白求恩医科大学生理教研室，白求恩医科大学生理教研室，白求恩医科大学有机化学教研室，白求恩医科大学有机化学教研室，白求恩医科大学有机化学教研室 长春130021 中国，长春130021 中国，长春 130021 中国，长春 130021 中国，长春 130021 中国，长春 130021 中国，长春 130021 中国，长春 130021 中国 |
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| 摘 要： | 目的:从东亚钳蝎蝎毒(BMK)中筛选有钠通道阻滞作用的活性成分.方法:培养小鼠心肌细胞,记录快反应动作电位,观察22种BMK蝎毒提取物3 mg·L~(-1)对动作电位的影响,并与河豚毒2.5 mg·L~(-1)、尼莫地平3 mg·L~(-1)、氯化钡24.4 mg·L~(-1)进行对照.结果:BMK-1及其它19种组分使除级化参数V_(max),APA,OS和MDP减小.其作用与河豚毒相似,而与尼莫地平和氯化钡不同.结论:快反应心肌细胞动作电位的改变表明,BMK蝎毒中的20种组分有钠通道阻滞作用.
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| 关 键 词： | 培养的细胞 心肌 动作电位 蝎毒 |
Influence of the 2nd and 3rd grade abstracts from scorpion venom of Buthus martensii Karsch on action potentials of fast response myocardiocytes |
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| JIANG Yan,LIU Wei,ZHONG Guo-Gan,YANG Shi-Jie,ZHANG Wen-Jie,WEI Jun-Jie,ZHANG Hong-Jun,WANG Lin. Influence of the 2nd and 3rd grade abstracts from scorpion venom of Buthus martensii Karsch on action potentials of fast response myocardiocytes[J]. Acta pharmacologica Sinica, 1995, 0(2) |
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| Authors: | JIANG Yan LIU Wei ZHONG Guo-Gan YANG Shi-Jie ZHANG Wen-Jie WEI Jun-Jie ZHANG Hong-Jun WANG Lin |
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| Abstract: | AIM: To screen the active components of sodium channel blockade action from Buthus martensii Karsch (BMK) scorpion venom. METHODS: Myocardiocytes of mice werecultured. Action potentials of fast response myocardiocytes were recorded. The effects of 22 contents of BMK scorpion venom in a concentration of 3 mg.L-1 were tested and compared with that of TTX 2. 5 mg . L-1, ni-modipine (Nim) 3 mg.L-1 and Bad; 24. 4 mg .L-1. RESULTS: BMK-1 and other 19 contents significantly decreased depolarization parameters Vmax, APA, OS, and MDP. which was similar to that of TTX and different from that of Nim and BaCl2. CONCLUSION: The variations in the action potentials of fast response myocardiolcytes indicated that 20 contents of BMK scorpion venom had sodium channel blockade action. |
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| Keywords: | cultured cells myocardium action potentials scorpion venoms |
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