Improvement of left ventricular function after percutaneous transluminal coronary angioplasty |
| |
Authors: | Ulrich Sigwart Milan Grbic Axel Essinger Angelika Bischof-Delaloye Hossein Sadeghi Jean-Louis Rivier |
| |
Institution: | From the Departments of Cardiology and Radiology and Nuclear Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland |
| |
Abstract: | Cardiac function and left ventricular dynamics were measured in seven consecutive patients 1 day before and 6 months after percutaneous transluminal balloon angioplasty of subtotal proximal stenosis of the left anterior descending coronary artery. Before angioplasty all patients had obvious left ventricular dysfunction during exercise and to a smaller degree during isoproterenol infusion; the condition of all patients was greatly improved 6 months after angioplasty. After angioplasty, left ventricular end-diastolic pressure was normal at rest and decreased from a mean (± standard error of the mean) of 33.8 ± 1.6 to 19.2 ± 0.5 mm Hg on exercise. Left ventricular ejection fraction, measured by a gated blood pooling technique with technetium-99m, improved on exercise from 46 ± 5.0 percent to 69 ± 1.0 percent. Cardiac output and stroke volume index increased significantly with exercise after angioplasty. The peak negative rate of pressure reduction in the left ventricle (dP/dt/min), an index of left ventricular relaxation, was highly abnormal on exercise before (2,307 ± 260 mm Hg/s) and increased to the normal range (3,154 ± 200 mm Hg/s) after angioplasty. The improvement in left ventricular function after transluminal angioplasty in these cases of proximal left anterior descending coronary arterial stenosis is extremely encouraging. |
| |
Keywords: | Address for reprints: Ulrich Sigwart MD Centre Hospitalier Universitaire Vaudois CH-1011 Lausanne Switzerland |
本文献已被 ScienceDirect 等数据库收录! |
|