| 壳聚糖载氟喹诺酮类药物缓释微球的研究进展 |
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| 引用本文： | 程鹏,关静,张华. 壳聚糖载氟喹诺酮类药物缓释微球的研究进展[J]. 国际生物医学工程杂志, 2009, 32(6). DOI: 10.3760/cma.j.issn.1673-4181.2009.06.007 |
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| 作者姓名： | 程鹏 关静 张华 |
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| 作者单位： | 300160,天津工业大学;300161,天津,军事医学科学院卫生装备研究所;军事医学科学院卫生装备研究所,天津,300161;天津工业大学,300160 |
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| 基金项目： | 天津市自然科学基金重点课题 |
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| 摘 要： | 壳聚糖载氟喹诺酮类药物微球是一类新型的抗菌缓释剂,它既具有壳聚糖的抗菌、抑菌性能,又能发挥氟喹诺酮类药物良好的杀菌作用.将氟喹诺酮类药物负载于壳聚糖微球,可大幅提升其抗菌、杀菌及消炎抗感染性能.综述了近几年壳聚糖载氟喹诺酮类药物缓释微球的制备方法及其应用研究进展.
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| 关 键 词： | 壳聚糖 氟喹诺酮 微球 缓释 纳米粒 |
Advances ion chitosan sustained-release microspheres containing fluoroquinolones |
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| CHENG Peng,GUAN Jing,ZHANG Hua. Advances ion chitosan sustained-release microspheres containing fluoroquinolones[J]. International Journal of Biomedical Engineering, 2009, 32(6). DOI: 10.3760/cma.j.issn.1673-4181.2009.06.007 |
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| Authors: | CHENG Peng GUAN Jing ZHANG Hua |
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| Abstract: | Chitosan microsphere containing fluoroquinolones is a kind of novel sustained-released antibacterial agent that possesses the antibacterial and bacteriostatic property of chitosan as well as bactericidal properties of fluoroquinolones. Loading fluoroquinolones in the chitosan microsphere can greatly enhance its antibacterial, bactericidal, anti-inflammation and anti-infection characteristics. This paper reviewes the recent study on different preparation methods of chitosan mierosphere containing fluoroqninolones and discusses its applications. |
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| Keywords: | Chitosan Fluoroquinolones Microsphere Sustained-release Nanoparticles |
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