依诺肝素钠不同给药方法治疗不稳定型心绞痛疗效的对比分析

目的　旨在探讨静脉推注依诺肝素钠加皮下注射与常规单纯皮下注射依诺肝素钠治疗不稳定型心绞痛的治疗效果。方法　 64例经临床症状、心电图、心脏超声或心肌酶谱明确诊断为不稳定型心绞痛的患者在扩冠、解痉、抗血小板聚集甚至溶栓治疗等常规治疗的基础上 ,随机分为两组 ,1组 :首剂依诺肝素钠静脉推注 ,按 1mg/kg给予 ,后按此剂量每 12h皮下注射 1次 ,共用 7d。 2组 :按 1mg/kg给予 ,每 12h皮下注射 1次 ,共用 7d。观察指标包括胸痛缓解、出血倾向、凝血全套、心电图、心超左室射血分数 (LVEF)以及室壁收缩活动的改善等。结果　经治疗 1周后 ,对比结果表明先静脉推注组在胸痛缓解程度、时间快慢、心电图ST段恢复、心功能及室壁活动改善方面明显优于单纯皮下注射组 (P <0 .0 5) ,且在出血等并发症方面无显著差异 (P >0 .0 5)。结论　先静脉推注依诺肝素钠治疗不稳定型心绞痛效果好 ,且安全可靠

COMPARISON BETWEEN THE EFFICACIES OF 2 REGIMENS OF ENOXAPRIAN IN TREATING UNSTABLE ANGINA

Objective To assess the clincal efficacy of first intravenous injection of enoxaprian,and then subcutaneous injection of enoxaprian every 12 hours for 7 days in unstable angina (UA).Methods Sixty four UA patients were randomly assigned to 2 group:group one (n=32) were given IV injection of enoxaprian (1 mg/kg) first and then subcutaneous injection of enoxaprian (1 mg/kg) every 12 hours for 7 days.Group two (n=32) were given subcutaneous injection of enoxaprian (1 mg/kg) every 12 hours for 7 days only.Evaluations of clinical curative effect,hemorrhage,ECG,LVEF, E/F were carried out before and after one week treatment.Results The efficacy of group one was better than that of group two (P<0.05).Conclusions It is more effective and safe to first inject enoxaprian from intravenous plus subcutaneous injection every 12 hours for 7 days in the treatment of unstable angina.