| 辽东楤木总皂苷降血糖作用研究 |
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| 引用本文： | 宋少江,徐绥绪,曹颖林. 辽东楤木总皂苷降血糖作用研究[J]. 中国现代中药, 2005, 7(5): 7-9 |
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| 作者姓名： | 宋少江 徐绥绪 曹颖林 |
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| 作者单位： | 沈阳药科大学中药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的测定辽东楤木总皂苷降血糖活性.方法:辽东楤木总皂苷以120,60,30mg·kg-1剂量连续灌胃给正常小鼠9d;以100,50,25mg·kg1剂量连续给药四氧嘧啶诱导高血糖家兔4周;以120,60,30mg·kg-1剂量单次给药链脲霉素致高血糖小鼠,并分别于给药后测定血糖值.结果:辽东楤木总皂苷连续给药120,60mg·kg-1两剂量组使受试正常小鼠血糖明显降低;总皂苷连续灌胃给药,可使四氧嘧啶高血糖家兔血糖值明显降低,且随给药时间延长其降糖作用日趋明显,停药后其降糖作用可维持2～4h;单次灌胃给药,三剂量组于给药后2、4h使链脲霉素诱导的高血糖小鼠血糖明显降低,与给药前比较有非常显著或显著差异.结论:辽东楤木总皂苷具有较好的降血糖活性.
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| 关 键 词： | 辽东楤木总皂苷 降血糖 四氧嘧啶 链脲霉素 |
| 收稿时间： | 2005-04-05 |
| 修稿时间： | 2005-04-05 |
Hypoglycemic effect of saponins from Aralia elata (Miq.) Seem |
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| Song Shaojiang,Xu Suixu and Cao Yinglin. Hypoglycemic effect of saponins from Aralia elata (Miq.) Seem[J]. Modern Chinese Medicine, 2005, 7(5): 7-9 |
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| Authors: | Song Shaojiang Xu Suixu Cao Yinglin |
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| Affiliation: | School of Traditional Chinese Materia Medica, Shenyang pharmaceutical University, Shenyang 110016, China;School of Traditional Chinese Materia Medica, Shenyang pharmaceutical University, Shenyang 110016, China;School of Traditional Chinese Materia Medica, Shenyang pharmaceutical University, Shenyang 110016, China |
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| Abstract: | Objective: To study the hypoglycemic effect of saponins from Aralia elata (Miq.) Seem.. Method: The effects of general saponins of Aralia elata (GSAE) was evaluated by using the normal rat and model of diabetic rat and rabit caused by alloxin and streptozotocin. Result: After administration of general saponins of Aralia elata, glycemia of normal and diabetic animal was decreased and this effect maintained for 2~4h. Conclusion: The general saponins from Aralia elata (Miq.) Seem. shown potent activity on antidiabetes. |
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| Keywords: | General Saponins of Aralia elata (GSAE) antidiabetic activity alloxin streptozotocin |
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