| 抗前列腺增生药SL—89．0519—08的合成 |
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| 引用本文： | 方浩,夏霖,沈万华,李敏勇,倪沛洲. 抗前列腺增生药SL—89．0519—08的合成[J]. 中国药科大学学报, 2002, 33(2): 20-22 |
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| 作者姓名： | 方浩 夏霖 沈万华 李敏勇 倪沛洲 |
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| 作者单位： | 中国药科大学药物化学教研室,南京,210009 |
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| 摘 要： | 目的：研究治疗前列腺增生的α1－受体拮抗剂SL－89．0519－08的合成路线。方法：以5－氯－2－甲氧基苯胺为原料，经环合，烃化，脱保护基和亲核取代等步骤，合成了目标化合物，同时对原料合成工艺进行了摸索。结果：合成的目标化合物经IR，^1HMNR,EI-MS和HRMS得以确证。结论：该合成工艺和路线适宜工业化生产。
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| 关 键 词： | SL－89.0591－08 α1－受体拮抗剂 抗前列腺增生 合成 |
| 文章编号： | 1000-5048(2002)02-0098-03 |
Synthesis of SL-89.0519-08 |
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| FANG Hao,XIA Lin,SHEN Wang Hu,LI Min Yong,NI Pei Zhou. Synthesis of SL-89.0519-08[J]. Journal of China Pharmaceutical University, 2002, 33(2): 20-22 |
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| Authors: | FANG Hao XIA Lin SHEN Wang Hu LI Min Yong NI Pei Zhou |
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| Affiliation: | FANG Hao,XIA Lin,SHEN Wang Hua,LI Min Yong,NI Pei Zhou Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | AIM The purpose is to make a research of synthetic scheme of adrenergic antagonist SL 89.0519 08 for the treatment of benign prostatic hyperplasia. METHODS Using 5 chloro 2 methoxyaniline, the target compound was synthesized after steps of cyclization, alkylation, deprotective group and nucleophilic substitution, meanwhile the synthetic method was studied. RESULTS The compound was confirmed by IR, 1HNMR,EI MS and HRMS. CONCLUSION This synthesis is suitable for industrial manufacture. |
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| Keywords: | SL-89.0591-08 |
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