The Fas counterattack: cancer as a site of immune privilege |
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| Authors: | O'Connell J Bennett M W O'Sullivan G C Collins J K Shanahan F |
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| Affiliation: | Dept of Medicine, Cork University Hospital, Ireland. J.OConnell@ucc.ie |
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| Abstract: | Resistance to apoptosis through the Fas receptor pathway coupled with expression of the Fas ligand might enable many cancers to deliver a pre-emptive strike or counterattack against the immune system. Therapeutic exploitation of this has exciting potential, but now seems more complex and hazardous than was first evident. |
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