| 二咖啡酰奎宁酸抗肝纤维化及脂质过氧化作用的实验研究 |
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| 引用本文： | 孙燕荣,董俊兴,吕秋军,郭绍明,张慧娟,屠爱萍,温利青,吴曙光.二咖啡酰奎宁酸抗肝纤维化及脂质过氧化作用的实验研究[J].军事医学科学院院刊,2002,26(1):39-42. |
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| 作者姓名： | 孙燕荣 董俊兴 吕秋军 郭绍明 张慧娟 屠爱萍 温利青 吴曙光 |
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| 作者单位： | 1. 第一军医大学药物研究所,广东广州,510515
2. 军事医学科学院放射医学研究所,北京,100850 |
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| 摘 要： | 目的 :观察二咖啡酰奎宁酸抗复合因素致大鼠肝纤维化及脂质过氧化作用。方法 :采用复合因素复制大鼠肝纤维化模型 ,以血清层连蛋白 (LN)、透明质酸 (HA)、丙二醛 (MDA)、一氧化氮 (NO)含量、肝组织光镜、电镜下形态学改变为观察内容 ,探讨二咖啡酰奎宁酸的治疗作用。结果 :二咖啡酰奎宁酸能够显著降低血清LN ,HA ,MDA ,NO含量 ,明显改善肝组织炎症及纤维化状态。结论 :二咖啡酰奎宁酸具有一定的抗肝纤维化及脂质过氧化作用
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| 关 键 词： | 二咖啡酰奎宁酸 肝纤维化 脂质过氧化作用 |
| 文章编号： | 1000-5501(2002)01-0039-04 |
| 修稿时间： | 2001年7月26日 |
Effects of dicaffeoylquinic acid against liver fibrosis and lipid peroxidation in rats:an experimental study |
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| Abstract: | Objective: To study the effects of dicaffeoylquinic acid (IBE5)against liver fibrosis and lipid peroxidation in rats.Methods:Complex factors were used to produce rat model of hepatic fibrosis.Serum laminin(LN),hyaluronic acid (HA),serum lipid peroxide malondialdehyde(MDA),nitrogen oxide (NO) and pathological change in liver tissue were observed.Results:Compared with the control group,degree of histological injury and collagen deposition in liver of IBE5 groups decreased significantly and serum levels of LN,HA,MDA,NO were significantly lower.Conclusions:These results suggest that IBE5 has certain effects against liver fibrosis and lipid peroxidation in experimental model in rats. |
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| Keywords: | dicaffeoylquinic acid liver fibrosis lipid peroxidation |
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