复康片对卡马西平抑制骨髓造血功能的预防作用

目的观察复康片对卡马西平抑制大鼠骨髓的预防作用.方法给大鼠服用卡马西平90 d,预防组分别给予复康片低剂量与高剂量,用超清晰度骨髓细胞分析系统及光镜观察大鼠髓骨髓粒细胞系各期比值、有核细胞增生度,骨髓病理组织学,并观察比较不同剂量对大鼠骨髓抑制的作用.结果复康片低剂量组大鼠骨髓有核细胞增生程度明显恢复(P＜0.05),高剂量组增生程度明显活跃(P＜0.01);高低剂量组成熟粒细胞(主要是分叶核粒细胞)比例均明显降低(P＜0.05);高剂量组还可明显降低淋巴细胞比值,骨髓粒细胞系各期比值趋于正常(P＜0.05).结论复康片可预防或拮抗卡马西平对大鼠骨髓造血功能的抑制.

Preventive Effect of Fukang Tablets on the Inhibition of Hematopoiesis of the Bone Marrow Induced by Carbamazepine

Objective To investigate the preventive effects of Fukang Tablets (FT) on the inhibition of rat bone marrow induced by carbamazepine (CBZ). Method The rats in the model control group were given CBZ for 90 days,and the rats in the prevention group were given a lower dose of FT and a higher dose of FT,respectively. In each group,the ratios of myeloid granulocyte series at various stages,the proliferation degree of myeloid karyocytes,and the marrow histopathological criteria were observed by a super-definition myeloid cell analysis system and a light microscopy and at the same time,the effects of FT at different doses on the inhibition of bone marrow induced by CBZ were compared. Results Marked restoration of myeloid karyocyte proliferation was seen in the lower FT dose group ( P <0.05),and more active myeloid karyocyte proliferation was seen in the higher FT dose group ( P <0.01);the ratios of various definitive myeloid granulocytes (mainly segmented granulocytes) were found markedly decreased in both FT groups ( P <0.05);it was also found that the ratio of lymphocytes markedly decreased and the ratios of myeloid granulocyte series at various stages tended to be normal in the higher FT dose group ( P <0.05). Conclusion FT can prevent or antagonize the inhibition of hematopoiesis of rat bone marrow induced by CBZ.