| 广东紫珠挥发油化学成分的GC-MS分析及体外抗菌活性 |
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| 作者姓名： | Jia A Yang YF Kong DY Xiao CC |
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| 作者单位： | 上海医药工业研究院/创新药物与制药工艺国家重点实验室 |
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| 基金项目： | 国家“重大新药创制”科技重大专项“十一五”计划资助项目(2009ZX09301-007) |
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| 摘 要： | 目的:分离和分析广东紫珠挥发油的化学成分,并考察其体外抗菌活性。方法:采用水蒸气蒸馏法提取广东紫珠挥发油,应用气质联用(GC-MS)法分析挥发油的化学成分,结合计算机检索技术对分离的化合物进行鉴定,应用色谱峰面积归一化法计算各成分的相对百分含量。结果:鉴定了38个化合物,占总离子流图峰面积的76.01%。广东紫珠挥发油对金黄色葡萄球菌、大肠杆菌和白色念珠菌显示出不同抗菌活性。结论:广东紫珠挥发油的主要化学成分是萜类化合物(59.25%),对金黄色葡萄球菌、大肠杆菌和白色念珠菌显示出不同的抗菌活性。
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| 关 键 词： | 广东紫珠 挥发油 气质联用 抗菌活性 |
GC-MS analysis of chemical constituents of essential oil from Callicarpa kwangtungensis and their antimicrobial activity |
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| Jia A,Yang YF,Kong DY,Xiao CC.GC-MS analysis of chemical constituents of essential oil from Callicarpa kwangtungensis and their antimicrobial activity[J].Jorunal of Chinese Medicinal Materials,2012,35(3):415-418. |
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| Authors: | Jia An Yang Yi-Fang Kong De-Yun Xiao Cheng-Cheng |
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| Institution: | State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China. jiaan930008@sina.com |
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| Abstract: | Objective: To analyze the chemical constituents of the essential oil from Callicarpa kwangtungensis and investigate their antimicrobial activity in vitro.Methods: The essential oil of Callicarpa kwangtungensis were extracted by steam distillaton.The chemical constituents were separated and analyzed by GC-MS.Their relative percentages were calculated with peak area normalization method.Results: 38 compounds were identified,accounting for 76.01 % of the peak area of the total ion-current chromatogram.The essential oil had different antimicrobial activities.Conclusion: The main constituent of the essential oil is terpenoids(59.25%),and showing different activities against Staphylococcus aureus,Escherichia coli and Candida albicans. |
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| Keywords: | Callicarpa kwangtungensis Chun Essential oil GC-MS Antimicrobial activity |
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